The BRCA1 gene was isolated in 1994; germline mutations of this gene are known to confer susceptibility to breast and ovarian cancer in high-risk families. Since its discovery, several mutations have been identified in this gene; these are scattered throughout the gene, and include insertion and deletion frameshifts, base substitutions, and inferred regulatory mutations. It role in the pathogen...

BACKGROUND Breast cancer is a polygenetic disorder with a complex inheritance pattern. Single nucleotide polymorphisms (SNPs), the most common genetic variations, influence not only phenotypic traits, but also interindividual predisposition to disease, treatment outcomes with drugs and disease prognosis. The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasi...

background: cardiac risk assessment with myocardial perfusion imaging (mpi) is a common practice for some elderly breast cancer patients who are candidates for operation. in rare cases the tumor may become visible in the images. case presentation: this is the report of a case with a huge slow-growing breast tumor suspicious for malignancy and presenting with methoxy-isobutyl-isonitrile (mibi) u...

circulating tumor cells (ctcs) recognition and characterization in the peripheral blood of patients with breast cancer have proven practical and predictive value in different studies. however, the clinical significance of ctcs enumeration and molecular characterization in thepersonalization of breast cancer diagnosis and treatment remains under the debate. a literature search in pubmed, web of ...

colorectal cancer most commonly metastasizes to the liver and lung. metastatic colon carcinoma (mcc) to the breast is extremely rare. krukenberg tumor is an uncommon metastatic tumor of the ovary. case presentation: a 38 years woman presented with abdominal pain. in evaluation colon cancer was diagnosed at stage 3. folfox chemotherapy was done. after one year she developed krukenberg tumor. few...

Germline mutations of the BRCA1 tumor suppressor gene on chromosome 17q are involved in a significant fraction of hereditary breast and ovarian cancers. Allelic deletions that include the BRCA1 locus are common in breast and ovarian cancers, implying that somatic mutations of this gene may play an important role in the more common sporadic forms of these tumors as well. The recent cloning of BR...

A gene called "prohibitin" was isolated as a candidate antiproliferating gene in rat liver cells. We have isolated the human homologue of the rat prohibitin gene and mapped it to chromosome 17q12-21 where a gene responsible for hereditary breast cancer was localized. DNA sequence analysis of 2 exons in this gene in 23 sporadic breast cancers, which showed loss of heterozygosity on the long arm ...

Array comparative genomic hybridization (CGH) has been popularly used for analyzing DNA copy number variations in diseases like cancer. In this study, we investigated 82 sporadic samples from 49 breast cancer patients using 1-Mb resolution bacterial artificial chromosome CGH arrays. A number of highly frequent genomic aberrations were discovered, which may act as "drivers" of tumor progression....

breast cancer is a malignant tumor and the most common cancer among american women that starts from cells of the breast. the growth of the size of data exceeds the ability of humans to analyze the data. so we need some intelligent machines that can analyze datasets intelligently for us. we propose a multi nominal logit model to evaluate correlation between risk factors of breast tumor. our mode...

Hereditary artifacts in BRCA1 gene have a significant contributory role in familial cases of breast cancer. However, its germline mutational penetrance in sporadic breast cancer cases with respect to Pakistani population has not yet been very well defined. This study was designed to assess the contributory role of germline mutations of this gene in sporadic cases of breast cancer. 150 cases of ...