AIM The study investigates the effects of magnesium nanovesicles on the memory processes performance in mice. MATERIALS AND METHODS L-a-phosphatidylcholine was used to obtain nano formulations as lipid vesicles systems stabilized thereafter with chitosan. The experiment was carried out on white Swiss mice, divided into 3 groups of 7 animals each, treated orally 7 consecutive days: Group I (Co...

OBJECTIVE Parkia biglobossa stem bark decoction is a popular medicinal plant preparation used as calming agent for tensed patients in traditional medicine. The aim of this study was to evaluate the effects of aqueous stem bark extract of Parkia biglobossa (AEPB) and its active fraction AEPBF3 on anxiety, spontaneous alternation behavior, and locomotor activity. The open field apparatus was used...

BACKGROUND Psychosis frequently occurs in Alzheimer's disease (AD), being associated with more severe cognitive decline, but the underlying mechanisms are unknown. OBJECTIVE To investigate the effect of centrally administered beta-amyloid peptide, a model for AD, in the locomotor response to amphetamine, caffeine and MK-801, which are psychoactive drugs related to neurochemical changes occurr...

Complex collective activity emerges spontaneously in cortical circuits in vivo and in vitro, such as alternation of up and down states, precise spatiotemporal patterns replay, and power law scaling of neural avalanches. We focus on such critical features observed in cortical slices. We study spontaneous dynamics emerging in noisy recurrent networks of spiking neurons with sparse structured conn...

D-amino acid oxidase (DAO, DAAO) is an enzyme that degrades D-serine, the primary endogenous co-agonist of the synaptic Nmethyl-D-aspartate receptor. Convergent evidence implicates DAO in the pathophysiology and potential treatment of schizophrenia. To better understand the functional role of DAO, we characterized the behaviour of the first genetically engineered Dao knockout (Dao / ) mouse. Ou...

Hyperactivity within the ventral hippocampus (vHPC) has been linked to both psychosis in humans and behavioral deficits in animal models of schizophrenia. A local decrease in GABA-mediated inhibition, particularly involving parvalbumin (PV)-expressing GABA neurons, has been proposed as a key mechanism underlying this hyperactive state. However, direct evidence is lacking for a causal role of vH...

The ground-state phases of mixed diamond chains with bond alternation δ, and \((S,\tau^{(1)},\tau^{(2)}) = (1/2,1/2,1)\), where S is the magnitude vertex spins, τ(1) τ(2) are those apical investigated. two spins in each unit cell connected by an exchange coupling λ. couplings between take values 1 + δ − alternatingly. This model has infinite number local conservation laws. For large λ ≠ 0, grou...

Spontaneous brain activity has been recently characterized by avalanche dynamics with critical features for systems in vitro and in vivo. In this contribution we overview the experimental results and discuss a modelling approach implementing several physiological properties of living neurons which is able to reproduce experimental results for avalanche statistics. The temporal organization of a...

Spontaneous brain activity has been recently characterized by avalanche dynamics with critical features for systems in vitro and in vivo. In this contribution we present a review of experimental results on neuronal avalanches in cortex slices, together with numerical results from a neuronal model implementing several physiological properties of living neurons. Numerical data reproduce experimen...