A 60-year-old man presented to our hospital with a chief complaint of dysphagia. Barium swallow examination showed a filling defect in the upper thoracic esophagus, and gastrointestinal endoscopy revealed a polypoid tumor, 4 cm in size, accompanied by an ulcerative lesion at the top of the tumor, which indicated carcinosarcoma or squamous cell carcinoma (Fig. 1). Contrast-enhanced computed tomo...

Spindle cell carcinoma (SpCC) or sarcomatoid carcinoma is a highly malignant variant of squamous cell carcinoma which comprises 2% to 3% of all laryngeal cancers. It is considered to be a biphasic tumor that is composed of a squamous cell carcinoma (in situ or invasive) and spindle cell carcinoma with sarcomatous appearance. Most spindle cell tumors are polypoid and pedunculated; they are often...

Cell division is a highly regulated process and involves sequential activation and deactivation of a number of proteins. Mitotic protein kinase (MPS1) is a part of the spindle assembly checkpoint (SAC) activated during prometaphase and metaphase that prevents chromosome misalignment by arresting the cell in mid-mitosis until all of the chromosomes is properly attached to the mitotic spindle [1]...

PURPOSE To describe a case of anterior uveal spindle cell tumor in a cat with features similar to spindle cell tumor of blue eyed dogs. METHODS A 10-year-old female spayed domestic short-haired cat was referred for an iris mass OS. The mass was solitary, nodular, nonpigmented, located medially, and causing dyscoria. A diagnosis of a benign epithelial tumor was suggested by a FNA of the mass. ...

Most primary bladder tumors in children are predominantly malignant mesenchymal tumors, usually rhabdomyosarcoma. Several uncommon non-urothelial bladder tumors have been described and must be differentiated from sarcomatoid carcinoma. These include postoperative spindle cell nodule, inflammatory myofibroblastic tumor, leiomyoma, hemangioma and neurofibromas. IMT usually affects adolescents. Th...

Myoepithelial neoplasms of the soft tissues are a rare, heterogeneous group of tumors for which classification continues to evolve. While well defined within salivary glands, they can also arise in viscera and soft tissues, where diagnosis is challenging due to the lack of clinical and pathological familiarity. We present the case of a 36 year old man with myoepithelial carcinoma arising as a p...

Solitary fibrous tumor (SFT) is a mesenchymal tumor characterized by ovoid cells, branching blood vessels, stromal hyalinization, and CD34 immunoreactivity. Studies have shown loss of 13q in a group of morphologically similar entities, including cellular angiofibroma, mammary-type myofibroblastoma, and spindle cell lipoma. The histologic and immunophenotypic overlap between SFT and the latter g...

Background: Spindle cell/Sclerosing rhabdomyosarcoma is the rarest variant of rhabdomyosarcoma, accounting for 5-10% all cases. Pathologically, these tumors can provide a variety features and resemble other tumors, thus often difficult to diagnose. We report case sclerosing gingiva with histomorphology mimicking malignant peripheral nerve sheath tumor. Case Presentation: The patient was 39-year...

background and objective: inflammatory pseudotumor  is a lesion composed of proliferating spindle cells with mixed inflammatory infiltrates. some authors have proposed the name inflammatory myofibroblastic tumor as a proper descriptive term rather than the vague inflammatory pseudotumor. the aim of this study was to verify the myofibroblastic origin of spindle cells in idiopathic orbital inflam...

Spindle cell lipoma located in the dermis is uncommon. The plexiform variant of this tumor is rare. In fact, only six cases of this variant have been described previously. We report herein a case of dermal plexiform spindle cell lipoma with prominent myxoid matrix. A 47-year-old male patient presented with a solitary, 2.2 cm-cutaneous mass in the right buttock region that had slowly increased i...