BACKGROUND Although nisoxetine has been shown to elicit infiltrative cutaneous local anesthesia, the inhibition of voltage-gated Na(+) channels by nisoxetine has not been reported. The aim of this study was to evaluate the effect of nisoxetine on Na(+) currents and its efficacy on spinal anesthesia. METHODS In in vitro studies, the voltage-clamp method was employed to examine whether nisoxeti...

The excitability curve of the H reflex conditioned by stimulation of a mixed nerve was studied in eight Parkinsonism patients, before and after L-dopa therapy. There was no significant variation between the two curves. However, there was a reduction of the normal early inhibition of the H reflex conditioned by exteroceptive stimulation. This indicates the presence of alterations in the organisa...

Background Early-onset scoliosis, when left untreated, leads to severe deformity. Until the last decade, treatment of progressive curves in young children often consisted of definitive spinal fusion. The recognition of thoracic insufficiency syndrome associated with definitive early fusion has led to the development of new surgical techniques developed to preserve spinal and thoracic growth in ...

STUDY DESIGN A retrospective study of 180 patients with lung cancer spinal metastases, wherein prognostic score-predicted survival was compared with actual survival. OBJECTIVE To evaluate and compare the accuracy of prognostic scoring systems in lung cancer spinal metastases. SUMMARY OF BACKGROUND DATA The modified Tokuhashi, Tomita, modified Bauer, and Oswestry scores are currently used to...

32 Epidural stimulation of the lumbosacral spinal cord has been used to facilitate standing and 33 voluntary movement after clinically motor complete spinal cord injury. It seems of importance to 34 examine how the epidurally evoked potentials are modulated in the spinal circuitry, and 35 projected to various motor pools. We hypothesized that chronically implanted electrode arrays 36 over the l...

abstract   objective: to evaluate and review our experience with pediatric spinal injuries and factors affecting outcome, the authors conducted a retrospective clinical study of 43 cases (32 boys, 11 girls) of pediatric spine injuries treated during four years (january 1999 to december 2003).   methods: forty-three children with spinal injuries were studied retrospectively over four years and w...

Background. Idiopathic scoliosis is a three-dimensional deformity of the spine and the trunk. The principle clinical method of estimation of the rotational deformity in the transversal plane of the body is the measurement of the angle of trunk rotation with a scoliometer. The aim of the study was to investigate the relationship between the angle of trunk rotation and the two radiological parame...

One hundred and sixty-seven patients with adolescent idiopathic scoliosis were allocated prospectively to one of three different groups for correction before undergoing posterior spinal fusion and Harrington instrumentation, In group 1 single curves were corrected by a Risser turnbuckle plaster jacket and double curves by halo-pelvic traction. In Group 2 patients performed Cotrel dynamic tracti...