spinal cord injury (sci) actuate to complex cellular and molecular interactions within the central nervous system in a heave to repair the initial tissue damage. the pathophysiology of acute spinal cord injury (sci) involves primary and secondary mechanisms. neuroinflammation is an important secondary injury process in sci. the local inflammatory microenvironment within the injured spinal cord ...

introduction: spinal cord injuries are accompanied with significant demyelination of axons and subsequent locomotor dysfunction. to identify the extent of damage following electrolytic lesion of ventrolateral white matter, essential area for initiation of locomotor activity, we assessed demyelination as well as alteration in motor performance. moreover, the protective effect of estradiol as a c...

typical nmo is characterized by simultaneous or sequential acute transverse myelitis and optic neuritis. spinal cord lesions extending over 3 or more vertebral segments and normal brain imaging are the typical mri findings in nmo. in typical cases with positive nmo antibody the diagnosis is easy but in seronegative and atypical cases with different clinical manifestations and mri features the d...

a high number of people in the world suffered from spinal cord injury (sci). spinal cord injuries are happen due to falls from height, accidents, climbing, sports and etc. emergency care according to the standards not performed immediately after sci. a significant enhancement in the number of mortality and complications was observed every year. the aim of this study is to prevent the mortality,...

abstract malignant spermatic cord tumor is rare. spermatic cord metastasis is less common and the prognosis of these patients is poor. here we report a case of unilateral spermatic cord metastasis from advanced gastric cancer. a 57-year-old male underwent total gastrectomy due to advanced gastric cancer. three years later, a painless hard palpable mass in the left inguinal area developed and th...

background: the aim of this research was to study the distribution and changes of glycoconjugates particularly their terminal sugars by using lectin histochemistry during mouse spinal cord development. methods: formalin-fixed sections of mouse embryo (10-16 fetal days) were processed for lectin histochemical method. in this study, two groups of horseradish peroxidase-labeled specific lectins we...

Background: Amylin and Salmon Calcitonin belong to the calcitonin family of peptides and have high affinity binding sites in the rat spinal cord. The aim of this study was to characterize receptors for Amylin and Salmon Calcitonin functionally in the spinal cord of rats. We assessed the expression of c-Fos in response to intraplantar formalin in the lumbar regions of the spinal cord in consciou...

INTRODUCTION Neck pain is a common musculoskeletal problem that up to 70% of the world population will experience at some point in their lives. Intramedullary spinal cord metastasis is an exceedingly rare complication of malignancy that affects less than 1% of all patients with cancer. CASE REPORT We report a case of a 61-year-old man who presented to primary care clinic with 1-month history ...

background and objective: deprenyl is a drug for the treatment of parkinson’s disease, where the dopaminergic neurons are the target of this drug. several reports also documented that deprenyl has an effect on the sensory and motor neurons. there are some reports about the mode of action of deprenyl on motoneurons as a neuroprotective agent, while others believe that deprenyl acts as a neurores...

background ischemic injury of the spinal cord during the surgical repair of thoracoabdominal aortic aneurysms might lead to paraplegia. although a number of different mechanisms have been proposed, the exact cause of paraplegia has remained unknown, hampering the development of effective pharmacologic or other strategies for prevention of this condition. a number of studies suggested that cyclo...