We present a confidence-based single-layer feed-forward learning algorithm SPIRAL (Spike Regularized Adaptive Learning) relying on an encoding of activation spikes. We adaptively update a weight vector relying on confidence estimates and activation offsets relative to previous activity. We regularize updates proportionally to item-level confidence and weight-specific support, loosely inspired b...

To signal the onset of salient sensory features or execute well-timed motor sequences, neuronal circuits must transform streams of incoming spike trains into precisely timed firing. To address the efficiency and fidelity with which neurons can perform such computations, we developed a theory to characterize the capacity of feedforward networks to generate desired spike sequences. We find the ma...

Single-unit recordings conducted during perceptual decision-making tasks have yielded tremendous insights into the neural coding of sensory stimuli. In such experiments, detection or discrimination behavior (the psychometric data) is observed in parallel with spike trains in sensory neurons (the neurometric data). Frequently, candidate neural codes for information read-out are pitted against ea...

How inhibition regulates dendritic excitability is critical to an understanding of the way neurons integrate the many thousands of synaptic inputs they receive. In this issue of Neuron, Müller et al. (2012) show that inhibition blocks the generation of weak dendritic spikes, leaving strong dendritic spikes intact.

Ventricular safety pacing (VSP) is used to avoid cross talk by delivering ventricular stimulus shortly after an atrial-paced event if ventricular-sensed event occurs. Although VSP is a protective feature that exists for decades in different pacing devices, there are some reports of unfavorable outcomes of this algorithm. More so, health care providers sometimes face difficulties in interpreting...

: in order to study the effect of different nitrogen levels on yield components and seed yield of three barley cultivars, an experiment was conducted in 2011-2012 in a research farm of farming building of islamic azad university khorasgan (isfahan) branch located in khatunabad village (latitude 32o /40' n and longitude 51o /48' e). a split plot layout within randomized complete block design wit...