نتایج جستجو برای: spi

تعداد نتایج: 3972  

Journal: :Journal of Systems and Software 2003
Mahmood Niazi David Wilson

Different advances have been made in the development of software process improvement (SPI) standards and models, e.g. capability maturity model (CMM), more recently CMMI, and ISO’s SPICE. However, these advances have not been matched by equal advances in the adoption of these standards and models in software development which has resulted in limited success for many SPI efforts. The current pro...

Journal: :The Journal of biological chemistry 2005
Louise Ford David B Guiliano Yelena Oksov Asim K Debnath Jing Liu Steven A Williams Mark L Blaxter Sara Lustigman

A novel filarial serine protease inhibitor (SPI) from the human parasitic nematode Onchocerca volvulus, Ov-SPI-1, was identified through the analysis of a molting third-stage larvae expressed sequence tag dataset. Subsequent analysis of the expressed sequence tag datasets of O. volvulus and other filariae identified four other members of this family. These proteins are related to the low molecu...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 1998
G T Colbern D J Dykes C Engbers R Musterer A Hiller E Pegg R Saville S Weng M Luzzio P Uster M Amantea P K Working

The topoisomerase I inhibitor GL147211C [7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-campto thecin trifluoroacetate], a camptothecin analogue, has significant activity in tumor cell cytotoxicity assays in vitro and antitumor activity in both animal tumor models and human patients. Its toxicity is significant, however, effectively limiting the amount of drug that can be administer...

Journal: :The Southeast Asian journal of tropical medicine and public health 2010
Pushpa Maurya Anil K Gulati Gopal Nath

Salmonella enterica serotype Typhi (S. Typhi) is a causative organism of typhoid fever. A number of Salmonella serovars express a capsular polysaccharide antigen known as Vi, the biosynthetic and export proteins of which are encoded within the viaB locus of Salmonella Pathogenicity Island -7 (SPI-7). SPI-7 is inserted between two partially duplicated copies of tRNA -pheU gene. We have investiga...

2008
MOHD HAIRUL

Software Process Improvement (SPI) became known in the last twenty years. SPI is crucial to augment software process capabilities in software companies to face present demanding and global market. There were numerous published studies in United States, Europe, Australia and North America. Yet, there was still being short of research and published studies on SPI in Malaysia. This research attemp...

Journal: :American journal of physiology. Cell physiology 2004
John Cuppoletti Danuta H Malinowska Kirti P Tewari Qiu-Ju Li Ann M Sherry Myra L Patchen Ryuji Ueno

The purpose of this study was to determine the mechanism of action of SPI-0211 (lubiprostone), a novel bicyclic fatty acid in development for the treatment of bowel dysfunction. Adult rabbit intestine was shown to contain mRNA for ClC-2 using RT-PCR, Northern blot analysis, and in situ hybridization. T84 cells grown to confluence on permeable supports were shown to express ClC-2 channel protein...

Journal: :Journal of immunology 2015
Stephen K H Li Lauren A Solomon Patricia C Fulkerson Rodney P DeKoter

Spi-C is an E26 transformation-specific family transcription factor that is highly related to PU.1 and Spi-B. Spi-C is expressed in developing B cells, but its function in B cell development and function is not well characterized. To determine whether Spi-C functions as a negative regulator of Spi-B (encoded by Spib), mice were generated that were germline knockout for Spib and heterozygous for...

Journal: :Infection and immunity 2005
Brian K Coombes Bryan A Coburn Andrew A Potter Susantha Gomis Kuldip Mirakhur Yuling Li B Brett Finlay

We have developed a novel ileal loop model for use in calves to analyze the contribution of Salmonella enterica serovar Typhimurium type III secretion systems to disease processes in vivo. Our model involves constructing ileal loops with end-to-end anastamoses to restore the patency of the small intestine, thereby allowing experimental animals to convalesce following surgery for the desired num...

Journal: :Molecular and cellular biology 1995
Y Kominato D Galson W R Waterman A C Webb P E Auron

Interleukin-1 beta (IL-1 beta) is produced primarily by stimulated monocytes, suggesting that the IL1B gene, which codes for this protein, depends upon at least one cell-type-specific factor. Our previous characterization of the IL1B promoter indicated that the region between -131 and +12 is sufficient to direct cell-type-specific expression of a reporter gene (F. Shirakawa, K. Saito, C.A. Bona...

Journal: :Quality & safety in health care 2010
Anam Parand Susan Burnett Jonathan Benn Sandra Iskander Anna Pinto Charles Vincent

OBJECTIVES To identify factors affecting doctors' engagement with the Safer Patients Initiative (SPI). DESIGN Qualitative interview study. SETTING Four organisations participating in phase 1 of the SPI programme, from four different geographical locations in the UK. PARTICIPANTS 34 staff members, comprising senior executive/management leads involved in the SPI programme, the principal SPI...

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