Previously, we reported the abrogation of quiescence and reduced survival in lymphocytes from Gimap5(sph/sph) mice, an ENU germline mutant with a missense mutation in the GTPase of immunity-associated protein 5 (Gimap5). These mice showed a progressive loss of peripheral lymphocyte populations and developed spontaneous colitis, resulting in early mortality. In this study, we identify the molecu...

This paper presents a new technique for modification of 3D terrains by hydraulic erosion. It efficiently couples fluid simulation using a Lagrangian approach, namely the Smoothed Particle Hydrodynamics (SPH) method, and a physically-based erosion model adopted from an Eulerian approach. The eroded sediment is associated with the SPH particles and is advected both implicitly, due to the particle...

We have carried out a comparison study of hydrodynamical codes by investigating their performance in modelling interacting multiphase fluids. The two commonly used techniques of grid and smoothed particle hydrodynamics (SPH) show striking differences in their ability to model processes that are fundamentally important across many areas of astrophysics. Whilst Eulerian grid based methods are abl...

This paper presents the implementation of an adaptive smoothed particle hydrodynamics (ASPH) method for high strain Lagrangian hydrodynamics with material strength. In ASPH, the isotropic kernel in the standard SPH is replaced with an anisotropic kernel whose axes evolve automatically to follow the mean particle spacing as it varies in time, space, and direction around each particle. Except for...

We compare the statistics of driven, supersonic turbulence at high Mach number using FLASH a widely used Eulerian grid-based code and PHANTOM, a Lagrangian smoothed particle hydrodynamics (SPH) code at resolutions of up to 512 in both grid cells and SPH particles. We find excellent agreement between codes on the basic statistical properties: a slope of k in the velocity power spectrum for hydro...

The Smoothed Particle Hydrodynamics (SPH) method is a Lagrangian approach that has been widely used to eliminate numerical dispersion for solving advection-dispersion equation (ADE) of groundwater solute transport under advection-dominated situations. It found accuracy SPH results severely deteriorated, when particles are irregularly distributed in model domain with heterogeneous hydraulic cond...

This paper presents SPLASH, a publicly available interactive visualisation tool for Smoothed Particle Hydrodynamics (SPH) simulations. Visualisation of SPH data is more complicated than for grid-based codes because the data is defined on a set of irregular points and therefore requires a mapping procedure to a two dimensional pixel array. This means that, in practise, many authors simply produc...

Smoothed Particle Hydrodynamics (SPH) has been established as one of the major concepts for fluid animation in computer graphics. While SPH initially gained popularity for interactive free-surface scenarios, it has emerged to be a fully fledged technique for state-of-the-art fluid animation with versatile effects. Nowadays, complex scenes with millions of sampling points, oneand two-way coupled...

Particle methods play an important role in the study of a wide variety of astrophysical fluid dynamics problems. The different methods currently in use are all variants of the socalled Smoothed Particle Hydrodynamics (SPH) scheme introduced by Lucy and Gingold & Monaghan more than twenty years ago. This paper presents a complete introduction to SPH in its modern form, and discusses some of the ...

A spectrin-based membrane skeleton is important for the stability and organization of the erythrocyte. To study the role of spectrin in cells that possess complex cytoskeletons, we have generated alpha-spectrin-deficient erythroleukemia cell lines from sph/sph mice. These cells contain beta-spectrin, but lack alpha-spectrin as determined by immunoblot and Northern blot analyses. The effects of ...