messenger rnas may be targeted by short 19-27 nt rnas generally called small none-coding rnas (snrnas), the role of mirnas among other snrnas has been more studied and is well known. many researches show that all compartments of risc, proteins and mirnas take part in this wide range of regulatory impacts. ago protein homologs plus mirnas and target mrnas form a silencing complex in p-bodies whi...

Despite the father transmitting half the heritable information to the embryo the focus on preconception health has largely been on the mother. New studies highlight the role of the father in disease transmission via non-genetic inheritance, through epigenetic mechanisms. Epigenetic mechanisms include, DNA methylation, post-translational modifications of histones and noncoding RNAs. Paternal eff...

Urinary extracellular vesicles (uEV) hold non-invasive RNA biomarkers for genitourinary tract diseases. However, missing knowledge about reference genes and effects of preanalytical choices hinder biomarker studies. We aimed to assess how variables (urine storage temperature, isolation workflow) affect diabetic kidney disease (DKD)—linked miRNAs or kidney—linked mRNAs (kidney-RNAs) in uEV isola...

important aspect of sperm function such as motility and capacitation appear to be mediated at least partially though hyaloronic acid (ha). present study investigated effects of different doses of ha on sperm motility and vitality in human. sperm was obtained from 20 male from ivf clinic in imam khomeini hospital. sperm motility and vitality in human semen was analyzed according to who criteria ...

The female germline cells, i.e., the oocytes/eggs, contain a subpopulation of unique organelles and molecules (RNA and proteins) collectively called "the maternal determinants" that are indispensable for the determination of cell fate in the developing embryo. Although it has been known for some time that somatic cells deliver low-molecular-weight molecules to the oocyte/egg, the paradigm has b...

To investigate the potential core reproduction-related genes associated with the development of diabetes, the expression profiles of long noncoding RNA (lncRNA) and messenger RNA (mRNA) in the sperm of diabetic mice were studied. We used microarray analysis to detect the expression of lncRNAs and coding transcripts in six diabetic and six normal sperm samples, and differentially expressed lncRN...

[This corrects the article DOI: 10.1093/eep/dvw001.].

Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide. It has been proposed that the specific genotypes of Helicobacter pylori (H. pylori) are the causative agents in the development of gastroduodenal diseases, such as chronic atrophic gastritis, peptic ulcerations, and GC. However, disease progression to GC occurs in only a small proportion of infected patients. Re...