background:   objective: the aim of this study was to investigate the harmful effects of sodium arsenite on sperm parameters and the antioxidant effects of vit.e on sperm anomalies in sodium arsenite treated rats.   materials and methods: adult male rats were divided into 4 groups: control, sodium arsenite (8 mg/kg/day), vit.e (100 mg/kg/day) and sodium arsenite+vit.e. oral treatments were perf...

Several studies have shown that high concentrations of luteinizing hormone (LH) in the follicular phase of stimulation can have a negative effect on oocyte quality, pregnancy rate and incidence of miscarriage. The aim of the present study was to examine the effects of highly purified follicle stimulating/hormone (FSH HP) on ovarian stimulation and particularly on nuclear maturity and morphologi...

Since the beginning of the 1990s, when the first seizures of nuclear material were reported, the IAEA recorded more than 800 cases of illicit rafficking of nuclear or other radioactive materials. Despite the decreasing frequency of seizures involving nuclear materials (i.e. uranium or lutonium), the issue continues to attract public attention and is a reason for concern due to the hazard associ...

OBJECTIVE To localize foci of single-stranded (ss) DNA in sperm nuclei of fertile and infertile men. DESIGN Prospective, observational study. SETTING University infertility clinic. PATIENT(S) Semen samples from 12 consecutive asthenoteratospermic men presenting for infertility evaluation and 5 consecutive fertile men presenting for vasectomy. INTERVENTION(S) Semen analysis, semen proces...

The lectin, wheat germ agglutinin (WGA), has previously been shown to prevent transport into the cell nucleus. This paper shows that WGA also inhibits nuclear DNA replication, under the same conditions that prevent transport. Although WGA eliminates sperm nuclear DNA replication in a cell-free extract of Xenopus eggs, DNA synthesis on a single-stranded template proceeds normally. Inhibition of ...

BACKGROUND Research has suggested an association with ambient air pollution and sperm quality. OBJECTIVES We investigated the effect of exposure to ozone (O3) and particulate matter < 2.5 microm in aerodynamic diameter (PM2.5) on sperm quality. METHODS We reexamined a previous cohort study of water disinfection by-products to evaluate sperm quality in 228 presumed fertile men with different...

This study was aimed to assess the protective effects of Cornus mas fruit extract (CMFE) and vitamin E (Vit E) on sperm quality parameters in the methotrexate (MTX)-treated mice. Forty-eight young adult male mice (8-12 weeks) were randomly divided into six groups including control and test groups. The control group received normal saline orally , and the test groups were treated MTX (20 mg kg(-...

Objective: The aim of this study was to evaluate the effects of aging on semen quality in a population of infertile couples. Methods: A cross-sectional study of semen samples obtained from 1,500 men randomly selected from couples who attended an infertility clinic was conducted. The analyses were performed using Spearman’s correlation and Mann-Whitney tests. The age groups consisted of men ≤ 35...

Sperm nuclear transfer or intracytoplasmic sperm injection (ICSI) is a powerful assisted reproductive technology (ART) for treating human male infertility. Controversial reports of increased birth defects have raised concerns about the ART's safety. The cause for birth defects, however, has remained elusive for analysis in human because of the sample size, male infertility genetics, physiologic...

OBJECTIVES To investigate the presence of Poly (ADP-ribose) polymerase (PARP) and evaluate its function in ejaculated spermatozoa. DESIGN Experimental study. SETTING Reproductive Research Center. PATIENT(S) Semen specimens from 18 healthy donors and 12 infertile males. INTERVENTION(S) Ejaculated spermatozoa were subjected to sperm fractionation with a double-layer density gradient, prot...