نتایج جستجو برای: sperm epigenome markers

تعداد نتایج: 260809  

Sadeghi MR

Semen analysis is the frontline and old reliable test in the assessment of male fertility, but it failed to provide absolute prediction of sperm function and its fertilizing ability. A wide variety of internal and external factors affect sperm function without discernible and significant effects on semen analysis. Oxygen toxicity and oxidative stress (OS) are inherent challenge of living cells ...

Journal: :Reproductive toxicology 2012
Carlos Guerrero-Bosagna Trevor R Covert Md M Haque Matthew Settles Eric E Nilsson Matthew D Anway Michael K Skinner

The endocrine disruptor vinclozolin has previously been shown to promote epigenetic transgenerational inheritance of adult onset disease in the rat. The current study was designed to investigate the transgenerational actions of vinclozolin on the mouse. Transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 ...

Journal: :Asian journal of andrology 2012
Ina O Specht Marcello Spanò Karin S Hougaard Gian C Manicardi Davide Bizzaro Gunnar Toft Aleksander Giwercman Jens-Peter E Bonde

Apoptosis in the testis has two putative roles during normal spermatogenesis; limitation of the germ cell population to numbers that can be supported by the Sertoli cells, and, possibly, selective depletion of meiotic and postmeiotic abnormal germ cells. We investigated the demographic and biological correlates of the pro-apoptotic marker Fas and the anti-apoptotic marker Bcl-xL in sperm cells ...

Journal: :Biology letters 2009
John L Fitzpatrick Jonathan P Evans

Inbreeding causes increases in homozygosity and is commonly associated with reductions in fertility and embryogenesis. Although the mechanisms underlying such effects are unknown, recent work has suggested that inbred males may suffer impaired ejaculate quality, thus providing a functional explanation for reductions in reproductive function in inbred populations. However, the relationship betwe...

2016
Juliette Dabin Anna Fortuny Sophie E. Polo

Organism viability relies on the stable maintenance of specific chromatin landscapes, established during development, that shape cell functions and identities by driving distinct gene expression programs. Yet epigenome maintenance is challenged during transcription, replication, and repair of DNA damage, all of which elicit dynamic changes in chromatin organization. Here, we review recent advan...

Journal: :Poultry science 1998
D J McLean A J Feltmann D P Froman

Centrifugation is commonly used to wash sperm; however, most washing techniques do not put sperm in a chemically defined environment. Rather, washing by centrifugation, in effect, dilutes seminal plasma components. A 0.5-mL volume of 30% (wt/vol) Accudenz was layered beneath 5 mL of 12% (wt/vol) Accudenz in a 15-mL polypropylene centrifuge tube. Diluted semen from individual males (n = 10) was ...

Journal: :Genes 2023

Smoking has been linked to male infertility by affecting the sperm epigenome and genome. In this study, we aimed determine possible changes in transcript levels of PGAM5 (the phosphoglycerate mutase family member 5), PTPRN2 (protein tyrosine phosphatase, N2-type receptor), TYRO3 (tyrosine protein kinase receptor) heavy smokers compared non-smokers, investigate their association with fundamental...

Journal: :Cellular reprogramming 2012
Mohammad Hadi Sekhavati Farshad Shadanloo Morteza S Hosseini Mojtaba Tahmoorespur Mohammad Reza Nasiri Mahdi Hajian Mohammad H Nasr-Esfahani

Despite widespread application of intracytoplasmic sperm injection (ICSI) in human-assisted reproductive techniques (ART), the efficiency of this method is still far from satisfactory in livestock, particularly in the bovine species with its unique sperm condensation. On the basis of the natural chemical structure of chromatin in condensed sperm, we developed a novel combined heparin-reduced gl...

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