Routing of channels between elementary fluidic elements is an important stage in the design new devices. This paper considers usage skeletons polygonal figures and compound splines routing circuits.

We study the identification capacity of classical-quantum channels (“cq-channels”), under channel uncertainty and privacy constraints. To be precise, we consider first compound memoryless cq-channels and determine their identification capacity; then we add an eavesdropper, considering compound memoryless wiretap cqq-channels, and determine their secret identification capacity. In the first case...

In this paper, an analogue of hirsutine (compound 1) has been synthesized and evaluated as an anti-hypertension agent, which exhibits extraordinary effects on the contractile response of thoracic aorta rings from male SD rats in vitro (IC50 = 1.129×10(-9)±0.5025) and the abilities of reducing the systolic blood pressure (SBP) and heart rate (HR) of SHR in vivo. The mechanism investigation revea...

Discovery of K+ channel modulators is limited by low-throughput capacity of existing K+ channel assays. To enable high-throughput screening for novel pharmacological modulators of K+ channels, we developed an assay based on growth of yeast that functionally expresses mammalian Kir2.1 channels. Screening of 10,000 small molecules from a combinatorial chemical library yielded 42 potential Kir2.1 ...

Abstract Accurate prediction of water surface profile in an open channel is the key to solving numerous critical engineering problems. The goal current research predict a compound with converging floodplains using machine learning approaches, including gene expression programming (GEP), artificial neural networks (ANNs), and support vector machines (SVMs), terms both geometric flow variables, a...

Deactivation of voltage-gated potassium (K(+)) channels can slow or prevent the recovery from block by charged organic compounds, a phenomenon attributed to trapping of the compound within the inner vestibule by closure of the activation gate. Unbinding and exit from the channel vestibule of a positively charged organic compound should be favored by membrane hyperpolarization if not impeded by ...