The clustered regularly interspaced short palindromic repeats (CRISPR) system has been adopted for a wide range of biological applications including genome editing. In some cases, dissection of genome functions requires allele-specific genome editing, but the use of CRISPR for this purpose has not been studied in detail. In this study, using the p16INK4a gene in HCT116 as a model locus, we inve...

locus of control is a very important issue in the psychological science and it can help people to overcome many psychological disorders. the main assumption of the present study was the relationship between both internal and external locus of control, as a hypothetical variable. the aim of this study was to determine the relationship between locus of control and levels of anxiety in female stud...

The pigment cell-specific gene, located at the brown (b) locus in mouse, has been cloned and characterized. Its gene product is required for the formation of black melanin rather than brown, although its exact function remains to be elucidated. We thus tentatively named it b-locus protein in this report. The b-locus protein gene is about 18 kilobase pairs long and organized into 8 exons and 7 i...

calpastatin (cast) is a specific inhibiter of calpains, playing a role in meat tenderization and myogenesis. in the present study the polymorphism of the cast gene ofkhalkhali goat in azerbaijan province in iran was investigated by polymerase chain reaction and restriction fragment length polymorphism technique (pcr-rflp). genomic dna was extracted from whole blood samples collected from 200 kh...

Background: Infertility as an important life stressor causes increased distress. The way of dealing with stress in individuals is different depending on the health locus of control. Also self- efficacy as an essential indicator of mental health determines how people cope with infertility. This study aimed to investigate the association of self efficacy with health locus of control and psycholog...

Data from experiments on the induction of specific-locus mutations in model systems are used in genetic risk assessment to estimate potential adverse effects in the human population. In such assessments with radiation or chemical mutagens, the following information is required: a) spontaneous and induced forward-mutation frequencies, b) dose-response curves for the overall induction of specific...