A highly accurate method for the determination of the detection efficiency of a silicon single-photon avalanche diode (Si-SPAD) is presented. This method is based on the comparison of the detected count rate of the Si-SPAD compared to the photon rate determined from a calibrated silicon diode using a modified attenuator technique, in which the total attenuation is measured in two attenuation st...

sCMOS imagers are currently utilized (replacing EMCCD imagers) to increase the acquisition speed in super resolution localization microscopy. Single-photon avalanche diode (SPAD) imagers feature frame rates per bit depth comparable to or higher than sCMOS imagers, while generating microsecond 1-bit-frames without readout noise, thus paving the way to in-depth time-resolved image analysis. High ...

Current instruments used to detect specific protein-protein interactions in live cells for applications in high-content screening (HCS) are limited by the time required to measure the lifetime. Here, a 32 × 1 single-photon avalanche diode (SPAD) array was explored as a detector for fluorescence lifetime imaging (FLIM) in HCS. Device parameters and characterization results were interpreted in th...

This study was conducted to determine the effects of different irrigation water treatments and silicon doses on leaf SPAD meter readings, chlorophyll content carotenoid contents tomato plants. Tybiff Aq seedling were grown in 3-liter pots filled with 1100 g 1:1 peat-perlite mixture for 70 days. Four type waters prepared use sea tap water. Irrigation included I) Full water, II) ½ + III) ¼ ¾ IV) ...

The appearance of miniaturized single-photon detectors has enabled massively parallel conversion of photons to digital signals that can be readily processed and/or transported with negligible losses. As a consequence, a new class of imaging sensors is emerging, known collectively as all-digital image sensors, for detection and processing of ultra-fast and complex photonic events, often present ...

ABSTRACT Portable chlorophyll meters can be used to improve the prediction of nitrogen (N) doses for common bean. This study aimed evaluate two (Minolta SPAD-502 and ClorofiLOG CFL 1030) predict topdressing N Pérola, TAA Gol BRSMG Uai cultivars VR 20 line. Eight field experiments (four genotypes devices) were carried out in a randomized blocks design, with four replicates, being treatments appl...

3D imaging and multi-pixel rangefinding constitute one of the most important and innovative fields of research in image sensor science and engineering in the past years. In rangefinding, one computes the Time-Of-Flight of a ray of light, generated by a mono-chromatic or wide-spectral source, from the source through the reflection of a target object and to a detector. There exist at least two te...

The design and measurements of a CMOS 64 × 64 Single-Photon Avalanche-Diode (SPAD) array with in-pixel Time-to-Digital Converter (TDC) are presented. This paper thoroughly describes the imager at architectural and circuit level with particular emphasis on the characterization of the SPAD-detector ensemble. It is aimed to 2D imaging and 3D image reconstruction in low light environments. It has b...

BACKGROUND Whilst large vessel vasculitis (LVV) predominantly occurs in isolation, associations with other infectious and non-infectious diseases have been reported. Limited data describing associations with various autoimmune diseases (AI), including spondyloarthritis exists. The aim of this study was to characterize the association of LVV and spondyloarthritis or its associated diseases (SpAD...