نتایج جستجو برای: sortilin

تعداد نتایج: 403  

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2008
Si Jin Fan Yi Fan Zhang Justin L Poklis Pin-Lan Li

OBJECTIVE The purpose of this study was to determine whether lysosome trafficking and targeting of acid sphingomyelinase (ASMase) to this organelle contribute to the formation of lipid raft (LR) signaling platforms in the membrane of coronary arterial endothelial cells (CAECs). METHODS AND RESULTS By measurement of fluorescent resonance energy transfer (FRET), it was found that in FasL-stimul...

Journal: :Annals of neurology 2011
Christiane Reitz Shinya Tokuhiro Lorraine N Clark Christopher Conrad Jean-Paul Vonsattel Lili-Naz Hazrati András Palotás Raphael Lantigua Martin Medrano Ivonne Z Jiménez-Velázquez Badri Vardarajan Irene Simkin Jonathan L Haines Margaret A Pericak-Vance Lindsay A Farrer Joseph H Lee Ekaterina Rogaeva Peter St George-Hyslop Richard Mayeux

OBJECTIVE Sorting mechanisms that cause the amyloid precursor protein (APP) and the β-secretases and γ-secretases to colocalize in the same compartment play an important role in the regulation of Aβ production in Alzheimer's disease (AD). We and others have reported that genetic variants in the Sortilin-related receptor (SORL1) increased the risk of AD, that SORL1 is involved in trafficking of ...

Journal: :Neuron 2010
Jada Lewis Todd E. Golde

Mutations within the granulin (GRN) gene that encodes progranulin (PGRN) cause the neurodegenerative disease frontotemporal lobar degeneration with ubiquitin inclusions (FTLD-U). The receptor for PGRN in the CNS has not been previously identified. In this issue of Neuron, Hu and colleagues identify Sortilin (SORT1) as a key neuronal receptor for PGRN that facilitates its endocytosis and regulat...

Journal: :Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2013
Maria Francisca Coutinho Mafalda Bourbon Maria João Prata Sandra Alves

Plasma low-density lipoprotein cholesterol (LDL-C) levels are a key determinant of the risk of cardiovascular disease, which is why many studies have attempted to elucidate the pathways that regulate its metabolism. Novel latest-generation sequencing techniques have identified a strong association between the 1p13 locus and the risk of cardiovascular disease caused by changes in plasma LDL-C le...

Journal: :Communicative & Integrative Biology 2017

2018
Jennifer Hirst Daniel N Itzhak Robin Antrobus Georg H H Borner Margaret S Robinson

The AP-5 adaptor protein complex is presumed to function in membrane traffic, but so far nothing is known about its pathway or its cargo. We have used CRISPR-Cas9 to knock out the AP-5 ζ subunit gene, AP5Z1, in HeLa cells, and then analysed the phenotype by subcellular fractionation profiling and quantitative mass spectrometry. The retromer complex had an altered steady-state distribution in th...

2013
Guanrong Huang Dana Buckler-Pena Tessa Nauta Maneet Singh Agnes Asmar Jun Shi Ju Youn Kim Konstantin V. Kandror

Insulin-dependent translocation of glucose transporter 4 (Glut4) to the plasma membrane of fat and skeletal muscle cells plays the key role in postprandial clearance of blood glucose. Glut4 represents the major cell-specific component of the insulin-responsive vesicles (IRVs). It is not clear, however, whether the presence of Glut4 in the IRVs is essential for their ability to respond to insuli...

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