A novel approach using a semipermeable Teflon AF-2400 tube-in-tube membrane contactor was developed for the measurement of gas solubility in organic solvents. This membrane ensures gas saturation of liquids in continuous flow at a specific pressure and temperature. After liquid decompression, the amount of gas outgassed was measured with a bubble meter and used for solubility calculation. The p...

Aqueous solubility is one of the most important ADMET properties to assess and to optimize during the drug discovery process. At present, accurate prediction of solubility remains very challenging and there is an important need of independent benchmarking of the existing in silico models such as to suggest solutions for their improvement. In this study, we developed a new protocol for improved ...

The chemistry of several calcium sulphate systems was successfully modelled in multi-component acid-containing sulphate solutions using he mixed solvent electrolyte (MSE) model for calculating the mean activity coefficients of the electrolyte species. The modelling involved the tting of binary mean activity, heat capacity and solubility data, as well as ternary solubility data. The developed mo...

In connection with the problem of the determination of the cardiac output by the use of ethylene (13), it seemed of interest to investigate further the nature of the forces which make the solubility of this gas 1% times as great in human blood as it is in water. The general problem of the nature of the factors which determine the solubility of gases in blood is of importance not only because of...

PURPOSE To provide predictive cosolvency models, the Abraham solvation parameters of solutes and the solvent coefficients were combined with the Jouyban-Acree and the log-linear models. These models require two and one solubility data points to predict the solubility of drugs in water-cosolvent mixtures. Ab initio prediction methods also were employed and the results were discussed. METHOD Th...

The solubility of sodium acetate in ternary solvent mixtures of water + methanol (MeOH) + acetonitrile (ACN), water + MeOH + 1-propanol (PrOH), water + PrOH + ACN, and MeOH + PrOH + ACN at 298.2 K is reported and mathematically represented using two numerical analyses (based on measured solubility data in 54 ternary mixtures containing the particular solvents in the mass fraction ranges between...

The capability of the extended forms, of two well established cosolvency models, i.e. the combined nearly ideal binary solvent/Redlich-Kister equation and the modified Wilson model, used to predict the solute solubility in non-aqueous ternary solvent mixtures is presented. These predictions are based on the measured solubilities of anthracene in binary solvent mixtures. As a result the values o...

AIM This study aimed to compare the solubility of a universal restorative resin composite (Filtek Z250; FZ250) and a silorane-based resin composite (Filtek Silorane; FS) after immersion in alcohol-containing mouthrinse, alcohol-free mouthrinse, and artificial saliva. METHODS 30 discs (10 mm × 1 mm) were prepared from each material and desiccated until a constant mass was obtained. Specimens w...

In a paper from this laboratory, describing the dependence of the solubility of the plasma proteins in concentrated salt solutions on the salt and plasma concentrations (l), we pointed out the advantage of using potassium phosphate as a precipitating salt inasmuch as the salt concentration and pH of such solutions could be varied independently as described by Cohn (2). For the specific purpose ...