in this paper, plate-like nio nanoparticles were prepared by one-pot solid-state thermal decomposition of nickel (ii) schiff base complex as new precursor. first, the nickel (ii) schiff base precursor was prepared by solid-state grinding using nickel (ii) nitrate hexahydrate, ni(no3)2∙6h2o, and the schiff base ligand n,n′-bis-(salicylidene) benzene-1,4-diamine) for 30 min without using any solv...

The near endless possibilities for assembling molecular materials has long posed a difficult challenge for theory. All crystal-structure prediction methods acknowledge the crucial contribution of van der Waals or dispersion interactions, but few go beyond a pairwise additive description of dispersion, ignoring its many-body nature. Here we use two databases to show how a many-body approach to d...

Solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. The poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. The purpose of the present investigation was to increase the solubility and dissolution rate of carve...

BACKGROUND Soluplus(®) (SP) and D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS)-based solid dispersion (SD) formulations were developed by hot-melt extrusion (HME) to improve oral bioavailability of valsartan (VST). METHODS HME process with twin-screw configuration for generating a high shear stress was used to prepare VST SD formulations. The thermodynamic state of the drug and ...

Motional averaging has been proven to be significant in predicting the chemical shifts in ab initio solid-state NMR calculations, and the applicability of motional averaging with molecular dynamics has been shown to depend on the accuracy of the molecular mechanical force field. The performance of a fully automatically generated tailor-made force field (TMFF) for the dynamic aspects of NMR crys...

The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68...

Solid dispersions traditionally have been used as effective methods to improve the dissolution properties and bioavailability of poorly water-soluble drugs. Furosemide a loop diuretic belonging to Biopharmaceutical Classification System (BCS) Class IV, has very poor water solubility. The aim of the present study was to improve the solubility and dissolution rate of a poorly water-soluble drug, ...

Nanostructured As2Ni3O8 samples were synthesized via facile solid-state reactions at 850 and 950 °C for 8h using As2O3, Ni(CH3COO)2.2H2O and Ni(NO3)2.6H2O raw materials. The synthesized nanomaterials were characterized by powder X-ray diffraction (PXRD) technique and fourier-transform infrared (FTIR) spectroscopy. The rietveld analyses showed that the obtained materials were crystallized well i...

polyvinylpyrrolidone (PVP) can markedly enhance the dissolution of poorly water-soluble drugs. The mechanism responsible for such enhanced dissolution has been the subject of debate. Some authors have proposed that the increased drug dissolution rate is due to the formation of a high-energy amorphous drug phase. Several water-soluble polymer carrier systems, such as polyethylene glycol (PEG), P...

The objective of the present study was to prepare amorphous solid dispersion system simvastatin–hydroxypropylmethylcellulose (HPMC) to enhance the dissolution rate. Amorphous solid dispersion of simvastatin was prepared by solvent technique using HPMC as carrier with ratio of 1:1, 1:3 and 1:5 (w/w). Physicochemical properties of solid dispersions were investigated by X-ray powder diffraction, t...