Objective: Methotrexate (MTX) is a folate antimetabolite used for the management of neoplastic diseases like leukemia and breast cancer, also in treatment psoriasis as well rheumatoid arthritis. The goal this research was to improving solubility dissolution profile methotrexate solid dispersion by using different polymers. Methods: A total six formulas were prepared solvent evaporation method p...

A solid dispersion of the drug can be made using a polymer carrier to improve solubility. Generally, drugs become amorphized when solid dispersion is formed using a polymer carrier. In such high energy conditions, the solubility of the drug molecule is increased. We previously prepared solid dispersion using a spray-drying technique and reported its solubility and crystallinity. In this study, ...

Surface solid dispersion with insoluble carriers is considered a recently developed technique, widely applied for the enhancement of solubility and dissolution of poorly water soluble drugs. The objective of this research article is to study the effect of surface solid dispersion of ketoprofen with colloidal silicon dioxide (Aerosil 200) on the dissolution rate. Surface solid dispersion (Adsorb...

The aim of the present study was to increase the solubility of a poorly water soluble BCS class II drug, valsartan. Liquisolid technology and solid dispersion by kneading method were techniques used to improve the solubility of the drug by using non-volatile solvents and some hydrophilic carriers. Liquisolid compacts were prepared by dissolving the drug in suitable non volatile solvents. The va...

The enhancement of oral bioavailability of poorly water-soluble drugs remains one of the most challenging aspects of drug development. Tadalafil a BCS class II drug is an impotence agent. It is indicated for the treatment of erectile dysfunction and is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5).However, insolubility and poor dissolut...

The influence of preparation methodology of silymarin solid dispersions using a hydrophilic polymer on the dissolution performance of silymarin was investigated. Silymarin solid dispersions were prepared using HPMC E 15LV by kneading, spray drying and co-precipitation methods and characterized by FTIR, DSC, XRPD and SEM. Dissolution profiles were compared by statistical and model independent me...

The purpose of this study was to obtain an amorphous system with minimum unit operations that will prevent recrystallization of amorphous drugs since preparation, during processing (compression) and further storage. Amorphous celecoxib, solid dispersion (SD) of celecoxib with polyvinyl pyrrollidone (PVP) and co-precipitate with PVP and carrageenan (CAR) in different ratios were prepared by the ...

lution property of poorly water soluble drugs. In general, solid dispersion is prepared with water soluble polymer, such as polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) as carrier, to disperse the drug molecules in the polymer matrix. Recently, the porous materials were also used as a carrier to disperse the drug molecules in the pores. We have already reported that the solid dispers...

The near endless possibilities for assembling molecular materials has long posed a difficult challenge for theory. All crystal-structure prediction methods acknowledge the crucial contribution of van der Waals or dispersion interactions, but few go beyond a pairwise additive description of dispersion, ignoring its many-body nature. Here we use two databases to show how a many-body approach to d...

Objective: The objective of the present investigation was to improve dissolution characteristics of EZE, which might offer improved bioavailability. Method: The solid dispersion of Ezetimibe was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, Sodium starch glycolate). The tablets were prepared by direct compression method. The compressed t...