Five new 3-(4-arylpiperazin-1-yl)-2-hydroxypropyl 4-propoxybenzoates were designed and synthesized as potential dual antihypertensive agents. The compounds were prepared as free bases and subsequently transformed to hydrochloride salts. The position of protonation of nitrogen atoms in the piperazine ring of hydrochloride salts was determined by means of (13)C-CP/MAS and (15)N-CP/MAS NMR and IR ...

2014 We present the first experimental results of X-ray diffraction on monodomains of two Schiff bases complexed with copper : the (DOBBA)2 2014Cu : Bis-[N(phényl-4n-butyl)(4n-dodecyloxy)-2-salicylideneamino]-Copper(II) and the (HOBBA)2 2014Cu : Bis-[N-(phényl-4n-butyl)(4n-heptyloxy)-2-salicylideneamino]-Copper(II), both in the smectic A phase and in a solid-like lower temperature phase. The re...

For the hybridization of single-stranded polynucleotides at a solid-liquid interface without any modifications of the polynucleotides, a self-assembled monolayer (SAM) containing anthryl groups which have an affinity for nucleic acid bases was prepared. The hybridization was investigated by surface plasmon resonance (SPR) and atomic force microscopy (AFM). Results of SPR measurement indicated t...

We realize indirect partial measurement of a transmon qubit in circuit quantum electrodynamics by interaction with an ancilla qubit and projective ancilla measurement with a dedicated readout resonator. Accurate control of the interaction and ancilla measurement basis allows tailoring the measurement strength and operator. The tradeoff between measurement strength and qubit backaction is charac...

Unnatural L-2'-deoxyribonucleosides L-T, L-dC, L-dA and L-dG were prepared from L-arabinose and assembled, by solution or solid phase synthesis, to give L-oligonucleotides (L-DNAs), which contain all four natural bases. The affinity of these modified oligomers for complementary D-ribo- and D-deoxyribo-oligomers was studied with NMR, UV and CD spectroscopies and mobility shift assay on native PA...

Phosphoramidite reagents can phosphitylate guanine bases at the O6-position during solid phase synthesis and serious chain cleavage occurs if the base phosphitylation is not eliminated before the iodine/water oxidation step. This can be accomplished by blocking the O6-position with a 2-cyanoethyl protecting group for deoxyribonucleotides or with a p-nitrophenylethyl group for ribonucleotides, r...

(The units can be presented as either single or double lectures) DNA origami pores DNA structure (primary, secondary, tertiary structure; A, B, Z-DNA; canonical and non-canonical base pairs, RNA vs DNA, Holiday and other multi-way junctions) DNA biochemistry (enzymatic synthesis, mechanism, replication fork, helicase) DNA chemistry (solid-phase synthesis, chemical modification at bases, nucleos...

The CRM is specified in a semantic data modelling style and relies on consolidated notions for the representation of knowledge such as classes, properties, IsA hierachies, domain and range constraints and cardinality restrictions. These notions are considered sufficiently clear and unambiguous both in the documentation and in the standardization communities. The CRM specification has been used ...

Adjusting the pH of water samples before performing solid-phase microextraction (SPME) analysis can be used to selectively extract organic acids (at pH 2) and bases (at pH 12). Sorption behavior of test organics is predictable based on the acid dissociation constant in water. In general, polyacrylate (PA) and Carbowax-divinylbenzene (CW-DVB) show substantially higher fiber/water sorption coeffi...

We report a systematic solid-state (17)O NMR study of free nucleic acid bases: thymine (T), uracil (U), cytosine (C), and guanine (G). Site-specifically (17)O-enriched samples were synthesized:[2-(17)O]thymine (1), [4-(17)O]thymine (2), [2-(17)O]uracil (3), [4-(17)O]uracil (4), [2-(17)O]cytosine (5), and [6-(17)O]guanine monohydrate (6). Magic-angle-spinning (MAS) and static (17)O NMR spectra w...