The prognostic value of long non-coding RNAs (lncRNAs) in patients with soft-tissue sarcoma has rarely been unraveled. The aim of the study was to find a lncRNA signature to predict the clinical outcome and survival in soft-tissue sarcoma based on the high-throughput RNA-seq data from The Cancer Genome Atlas (TCGA) database. The lncRNAs which closely correlated with overall survival in 258 soft...

----------------------------INDICATIONS AND USAGE--------------------VOTRIENT is a kinase inhibitor indicated for the treatment of patients with:  advanced renal cell carcinoma. (1)  advanced soft tissue sarcoma who have received prior chemotherapy. (1) Limitations of Use: The efficacy of VOTRIENT for the treatment of patients with adipocytic soft tissue sarcoma or gastrointestinal stromal tu...

Ewing’s sarcoma, an aggressive cancer of bone and soft tissue, primarily affects children young adults. A t(11;22) translocation is noted in 85 to 90% cases. Management includes surgery, radiotherapy, chemotherapy. The 5-year survival about 70%.

A case of retroperitoneal extraosseous Ewing's sarcoma (EES) with renal involvement, which simulated an exophytic renal mass, is reported. EES is a rare soft tissue tumor that can occur anywhere in the soft tissues, but is seen most commonly in the extremities. Although EES is histologically similar to osseous Ewing's sarcoma, it is usually found in older patients. EES should be included in the...

Multiple primary tumors in a single patient are relatively rare when four or more distinct lesions are considered. Herein, we report a case of woman with four different primary tumors: meningioma, renal angiomyolipoma, spinal ependymoma and high-grade soft tissue sarcoma. There was no family history and hereditary syndrome. The genetic analysis was completely normal. To best of our knowledge, t...

PET/MRI is an evolving hybrid imaging modality which combines the inherent strengths of MRIs soft-tissue and contrast resolution and PETs functional metabolic capabilities. Bone and soft-tissue sarcoma are a relatively rare tumor entity, relying on MRI for local staging and often on PET/CT for lymph node involvement and metastatic spread evaluation. The purpose of this article is to demonstrate...

Soft tissue sarcoma arising as a head and neck lesion is very rare in adults. Therefore, no standardized treatment exists for this entity of disease. We retrospectively analyzed 11 cases of head and neck soft tissue sarcomas treated at Osaka University Hospital from 1991 to 2011. They were pathologically classified as follows: 5 cases with rhabdomyosarcoma, 2 cases with liposarcoma, 2 cases wit...

Genetic aberrations responsible for soft-tissue sarcoma formation in adults are largely unknown, with targeted therapies sorely needed for this complex and heterogeneous family of diseases. Here we report that that the Hippo pathway is deregulated in many soft-tissue sarcomas, resulting in elevated expression of the effector molecule Yes-Associated Protein (YAP). Based on data gathered from hum...

A patient-derived nude-mouse model of soft-tissue sarcoma has been established and treated in the following groups: (1) untreated controls; (2) gemcitabine (GEM) (80 mg/kg, ip, weekly, 3 weeks); (3) Pazopanib (100 mg/kg, orally, daily, 3 weeks) and (4) Salmonella typhimurium A1-R (5 × 10(7) CFU/body, ip, weekly, 3 weeks). The sarcoma was resistant to GEM (p = 0.879). Pazopanib tended to reduce ...