In order to solve the problem of asymmetric large deformation high-stress soft rock crossing roadway under complex geological conditions in deep mines, taking 2# total return airway 76.2# section Wuyang Coal Mine as engineering background, causes and failure mines were summarized analyzed by means field investigation, theoretical analysis numerical simulation, high-efficiency support technology...

This study defined the height ratio of soft-rock strata and established a numerical model for analyzing shield construction in upper-soft, lower-hard composite together with field monitoring data. In this way, influence tunneling while passing under pile foundation culvert at short distance (the shortest is 1.4 m) typical Guangzhou can be examined. Moreover, reinforcement effects ground, bridge...

The physical properties of the extracellular matrix (ECM), such as stiffness, are involved in the determination of the characteristics of cancer cells, including chemotherapy sensitivity. Resistance to chemotherapy is often linked to dysfunction of tumor suppressor p53; however, it remains elusive whether the ECM microenvironment interferes with p53 activation in cancer cells. Here, we show tha...

Obtaining seismic images with good quality in hardrock environments has been challenging. This condition applies to many mineral explorations using seismic methods including our study area where the data quality is strongly affected by soft, near-surface materials and a reflector with low contrast in rock physical properties. Until recently, no effective processing has been applied to the seism...

This paper reviews the latest information and perspectives on global phosphorus scarcity. Phosphorus is essential for food production and modern agriculture currently sources phosphorus fertilizers from finite phosphate rock. The 2008 food and phosphate fertilizer price spikes triggered increased concerns regarding the depletion timeline of phosphate rock reserves. While estimates range from 30...

Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness. To better understand the effects of stiffness gradients on cell migration, we developed a 2.5D cell culture platform where cells are sandwiched be...