Arsenical compounds, known to be human carcinogens, were shown to disturb cell cycle progression and induce cytogenetic alterations in a variety of cell systems. We report here that a 24 h treatment of arsenite induced mitotic accumulation in human cell lines. HeLa S3 and KB cells were most susceptible: 35% of the total cell population was arrested at the mitotic stage after treatment with 5 mi...

Arsenic is a pathologic factor of cardiovascular diseases and cancers; nevertheless, it also acts as an anticancer agent effective on acute promyelocytic leukemia and multiple myeloma. Securin, a proposed proto-oncogene, regulates cell proliferation and tumorigenesis. However, roles of securin on the arsenic-induced cell cycle arrest and apoptosis remain unknown. In this study, the effects of s...

Arsenic as a toxic metalloid has been found to have potential carcinogenic effects of humans. However, pulmonary toxicity has not been fully elucidated. The purpose of this experiment is to test and observe the degree of toxicity of various concentrations of sodium arsenite (NaAsO2) on human lung epithelial cells (BEAS-2B cell line). In this experiment, BEAS-2B cells were plated and grown accor...

24 25 26 UN CO RR EC TE D PR Abstract. Selenium (Se) and arsenic are next-door neighbors on the periodic table and have similar chemical properties as metalloids. Arsenic antagonizes selenium toxicity in a number of organisms. Inorganic arsenic in drinking water is a human carcinogen while selenium compounds are anticarcinogenic in animals and humans. Our previous work showed that arsenite enha...

The Effect of Methylmercury. Tetraethyl Lead. and Sodium Arsenite on the Humoral Immune Response in Mice. BLAKLEY. B. R .. SISODIA. C. S .. AND MUKKUR. T. K. ( 19801. Toxicol. Appl. Pharmacol. 52, 245-254. Male mice were exposed to methylmercury. tetraethyl lead. or sodium arsenite for 3 weeks in the drinking water at three or four con· centrations ranging from 0.5 to 10.0 ppm. The humoral comp...

Arsenic is classified as a carcinogen for humans, but as a possible genotoxic agent. Thus, taking into account the controversial data about how arsenic compounds are able to induce genetic damage, we investigated the possible genotoxic activity of different arsenic compounds in the TK6 human lymphoblastoid cell line using the alkaline Comet assay. Eight different inorganic and organic arsenical...

Although epidemiologic evidence shows an association between inorganic arsenic in drinking water and increased risk of skin, lung, and bladder cancers, no animal model for arsenic carcinogenesis has been successful. This lack has hindered mechanistic studies of arsenic carcinogenesis. Previously, we and others found that low concentrations (< or =5 microm) of arsenite (the likely environmental ...

Objective: The main objective of the current study was to observe the ameliorative effect of Withania somnifera on arsenic-induced testicular toxicity by exploring the crucial parameters such as sperm counts, sperm motility, hormonal assay and lipid peroxidation including histopathology. Materials and Methods: In the present study, arsenic in the form of sodium arsenite was administered orally ...

Acidiphilium multivorum AIU 301 isolated from acid mineral water had strong arsenic resistance. This bacterium harbored a number of plasmids with different molecular sizes. A plasmid of 56 kbp, named pKW301, was isolated from A. multivorum AIU 301. When pKW301 was transferred into Escherichia coli JM109 by electroporation, an E. coli transformant carrying pKW301 exhibited resistance to sodium a...