Photosynthesis of leaf discs from transgenic tobacco plants (Nicotiana tabacum) that express a chimeric gene that encodes chloroplast-localized Cu/Zn superoxide dismutase (SOD+) was protected from oxidative stress caused by exposure to high light intensity and low temperature. Under the same conditions, leaf discs of plants that did not express the pea SOD isoform (SOD-) had substantially lower...

Superoxide dismutase (SOD) activities were determined for dietary dilution conditions that extend the life span of Drosophila melanogaster. The hypothesis motivating this research was that elevated SOD activity is associated with increased life span resulting from flies being held on a restricted diet. SOD activities were also measured for chico1 which is a mutation in the insulin receptor subs...

Background: Oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, Lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. The administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. The present study aimed to evaluate the radioprotective efficacy ...

In this paper, we consider several high-order schemes in one space dimension. In particular, we compare the second-order relaxation ( << 1) or “relaxed” ( = 0) schemes of Jin and Xin [Comm. Pure Appl. Math., 48 (1995), pp. 235–277] with the second-order Lax–Friedrichs scheme of Nessyahu and Tadmor [J. Comp. Phys., 87 (1990), pp. 408–463] and with higher-order essentially nonoscillatory (ENO) an...

Extracellular superoxide dismutase (EC-SOD) is the major isozyme of SOD in arteries, but is also abundant in lungs. In particular, mouse lungs contain large amounts of EC-SOD compared to lungs in other mammals. This suggests that EC-SOD may have an amplified function in the mouse lung. This study describes the purification and characterization of mouse EC-SOD as well as its localization in mous...

The development of improved seeded bermudagrass cultivars has led to an increased interest in these grasses for numerous areas of turfgrass use. One area that has yet to be investigated is the potential to produce sod using a seed-propagated bermudagrass, rather than the standard practice of vegetative propagation, which is currently used. To this end, a series of studies are underway to invest...

Superoxide dismutases (SODs) represent the major antioxidant defense system against superoxide anions (O2 ). Three isoforms of superoxide dismutase have been identified in mammals: copper-zinc SOD (Cu, ZnSOD), manganese SOD (Mn-SOD), and extracellular SOD (ecSOD). Cu, Znand Mn-SOD are localized intracellularly, whereas the last discovered SOD isoform, ecSOD,1 is secreted and bound to heparan su...

The role of Cu/Zn-superoxide dismutase (SOD) in myocardial ischemic reperfusion injury was studied by using a mouse model with targeted disruption of the mouse Sod I gene. Inactivation of the functional mouse Sod I gene in hearts by gene targeting (Sod I(+/-)) resulted in a 50% reduction of Cu/Zn-SOD mRNA and significant reduction of Cu/Zn-SOD enzyme activity compared with that of wild-type Sod...