نتایج جستجو برای: smo

تعداد نتایج: 1782  

Journal: :Current Biology 2008
Denis Combes Didier Le Ray François M. Lambert John Simmers Hans Straka

transport; both proteins belong to the RND superfamily of proteins, originally defined by bacterial channel and transporter proteins involved in resistance, nodulation and division. These similarities have led to the suggestion that Ptc might function by transporting antagonists or agonists of Smo across the plasma membrane. Two lines of evidence have provided support for such roles of Ptc: in ...

2010
S. V. N. Vishwanathan Zhaonan sun Nawanol Ampornpunt Manik Varma

Our objective is to train p-norm Multiple Kernel Learning (MKL) and, more generally, linear MKL regularised by the Bregman divergence, using the Sequential Minimal Optimization (SMO) algorithm. The SMO algorithm is simple, easy to implement and adapt, and efficiently scales to large problems. As a result, it has gained widespread acceptance and SVMs are routinely trained using SMO in diverse re...

2011
Martin F. Strand Steven R. Wilson Jennifer L. Dembinski Daniel D. Holsworth Alexander Khvat Ilya Okun Dirk Petersen Stefan Krauss

BACKGROUND Hedgehog (Hh) signaling is over-activated in several solid tumors where it plays a central role in cell growth, stroma recruitment and tumor progression. In the Hh signaling pathway, the Smoothened (SMO) receptor comprises a primary drug target with experimental small molecule SMO antagonists currently being evaluated in clinical trials. PRINCIPAL FINDINGS Using Shh-Light II (Shh-L...

2014
Kuan-Chung Chen Mao-Feng Sun Hsin-Yi Chen Cheng-Chun Lee Calvin Yu-Chian Chen

Nowadays, obesity becomes a serious global problem, which can induce a series of diseases such as type 2 diabetes mellitus, cancer, cardiovascular disease, metabolic syndrome, and stoke. For the mechanisms of diseases, the hedgehog signaling pathway plays an important role in body patterning during embryogenesis. For this reason, smoothened homologue (Smo) protein had been indicated as the drug...

2013
Kathryn E. O’Reilly Eleazar Vega-Saenz de Miera Miguel F. Segura Erica Friedman Laura Poliseno Sung Won Han Judy Zhong Jiri Zavadil Anna Pavlick Eva Hernando Iman Osman

Previous reports have demonstrated a role for hedgehog signaling in melanoma progression, prompting us to explore the therapeutic benefit of targeting this pathway in melanoma. We profiled a panel of human melanoma cell lines and control melanocytes for altered expression of hedgehog pathway members and determined the consequences of both genetic and pharmacological inhibition of the hedgehog p...

Journal: :Cancer research 2011
Gerrit J P Dijkgraaf Bruno Alicke Lasse Weinmann Thomas Januario Kristina West Zora Modrusan Dan Burdick Richard Goldsmith Kirk Robarge Dan Sutherlin Suzie J Scales Stephen E Gould Robert L Yauch Frederic J de Sauvage

Inappropriate Hedgehog (Hh) signaling has been directly linked to medulloblastoma (MB), a common malignant brain tumor in children. GDC-0449 is an Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent. Treatment of a MB patient with GDC-0449 initially regressed tumors, but this individual ultimately relapsed with a D473H resistance mutation in Smoothened (SMO)...

2018
Xueling Song Liying Yan Cuiling Lu Chunyu Zhang Fuli Zhu Jingjing Yang Hongyan Jing Yang Zhang Jie Qiao Hongyan Guo

Few studies have evaluated Hedgehog (Hh) signaling pathway activation in different types of ovarian tumors including benign, borderline and malignant ovarian tumors. The present study investigated the expression of Hh signaling pathway components (SHH, SMO, PTCH, and GLI1) in 193 ovarian epithelial tumor specimens (including 147 malignant epithelial ovarian cancers, 30 borderline ovarian tumors...

Journal: :Molecular cancer therapeutics 2014
Jasmin R Agarwal Qiuju Wang Toshihiko Tanno Zeshaan Rasheed Akil Merchant Nilanjan Ghosh Ivan Borrello Carol Ann Huff Farhad Parhami William Matsui

The Hedgehog (Hh) signaling pathway is aberrantly activated in a wide variety of human cancers, and recent clinical studies have demonstrated that pathway inhibitors are effective in advanced basal cell carcinoma (BCC). The majority of these agents have been designed to target SMOOTHENED (SMO), a transmembrane regulator of Hh signaling, but subsequent mutations in SMO have been found to generat...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2010
Kimberly Walter Noriyuki Omura Seung-Mo Hong Margaret Griffith Audrey Vincent Michael Borges Michael Goggins

PURPOSE Accumulating evidence suggests that cancer-associated stromal fibroblasts (CAF) contribute to tumor growth by actively communicating with cancer cells. Our aim is to identify signaling pathways involved in tumor-stromal cell interactions in human pancreatic cancer. EXPERIMENTAL DESIGN We established primary fibroblast cultures from human pancreatic adenocarcinomas and nonneoplastic pa...

Journal: :Development 2017
Benjamin E Armstrong Astra Henner Scott Stewart Kryn Stankunas

Zebrafish innately regenerate amputated fins by mechanisms that expand and precisely position injury-induced progenitor cells to re-form tissue of the original size and pattern. For example, cell signaling networks direct osteoblast progenitors (pObs) to rebuild thin cylindrical bony rays with a stereotypical branched morphology. Hedgehog/Smoothened (Hh/Smo) signaling has been variably proposed...

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