نتایج جستجو برای: smc1

تعداد نتایج: 209  

Journal: :Science 2014
Pim J Huis in 't Veld Franz Herzog Rene Ladurner Iain F Davidson Sabina Piric Emanuel Kreidl Venugopal Bhaskara Ruedi Aebersold Jan-Michael Peters

Chromosome segregation depends on sister chromatid cohesion mediated by cohesin. The cohesin subunits Smc1, Smc3, and Scc1 form tripartite rings that are thought to open at distinct sites to allow entry and exit of DNA. However, direct evidence for the existence of open forms of cohesin is lacking. We found that cohesin's proposed DNA exit gate is formed by interactions between Scc1 and the coi...

Journal: :The Journal of Cell Biology 2008
Nenggang Zhang Sergey G. Kuznetsov Shyam K. Sharan Kaiyi Li Pulivarthi H. Rao Debananda Pati

The cohesin complex is responsible for the accurate separation of sister chromatids into two daughter cells. Several models for the cohesin complex have been proposed, but the one-ring embrace model currently predominates the field. However, the static configuration of the embrace model is not flexible enough for cohesins to perform their functions during DNA replication, transcription, and DNA...

Journal: :The EMBO journal 2012
Silvia Remeseiro Ana Cuadrado Gonzalo Gómez-López David G Pisano Ana Losada

Vertebrates have two cohesin complexes that consist of Smc1, Smc3, Rad21/Scc1 and either SA1 or SA2, but their functional specificity is unclear. Mouse embryos lacking SA1 show developmental delay and die before birth. Comparison of the genome-wide distribution of cohesin in wild-type and SA1-null cells reveals that SA1 is largely responsible for cohesin accumulation at promoters and at sites b...

2014
Maurici B. Roig Jan Löwe Kok-Lung Chan Frédéric Beckouët Jean Metson Kim Nasmyth

Sister chromatid cohesion involves entrapment of sister DNAs by a cohesin ring created through association of a kleisin subunit (Scc1) with ATPase heads of Smc1/Smc3 heterodimers. Cohesin's association with chromatin involves subunits recruited by Scc1: Wapl, Pds5, and Scc3/SA, in addition to Scc2/4 loading complex. Unlike Pds5, Wapl, and Scc2/4, Scc3s are encoded by all eukaryotic genomes. Her...

2015
Gamze Çamdere Vincent Guacci Jeremiah Stricklin Douglas Koshland Peter Verrijzer

Cohesin tethers together regions of DNA, thereby mediating higher order chromatin organization that is critical for sister chromatid cohesion, DNA repair and transcriptional regulation. Cohesin contains a heterodimeric ATP-binding Cassette (ABC) ATPase comprised of Smc1 and Smc3 ATPase active sites. These ATPases are required for cohesin to bind DNA. Cohesin's DNA binding activity is also promo...

Journal: :Cell 1999
Yuval Blat Nancy Kleckner

Sister chromatid cohesion is mediated by evolutionary conserved chromosomal proteins, termed "cohesins." Using an extension of chromatin immunoprecipitation, we have analyzed the distribution of cohesins Mcd1/ Sccl and Smc1 along yeast chromosome III. Both proteins occur preferentially at the same approximately 23 positions. Sites in a approximately 50 kb region around the centromere give espec...

2017
Shuyu Li Zuojun Yue Tomoyuki U. Tanaka

Cohesins establish sister chromatid cohesion during S phase and are removed when cohesin Scc1 is cleaved by separase at anaphase onset. During this process, cohesin Smc3 undergoes a cycle of acetylation: Smc3 acetylation by Eco1 in S phase stabilizes cohesin association with chromosomes, and its deacetylation by Hos1 in anaphase allows re-use of Smc3 in the next cell cycle. Here we find that Sm...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2006
Raju V Pusapati Robert J Rounbehler SungKi Hong John T Powers Mingshan Yan Kaoru Kiguchi Mark J McArthur Paul K Wong David G Johnson

Overexpression of the c-myc oncogene contributes to the development of a significant number of human cancers. In response to deregulated Myc activity, the p53 tumor suppressor is activated to promote apoptosis and inhibit tumor formation. Here we demonstrate that p53 induction in response to Myc overexpression requires the ataxia-telangiectasia mutated (ATM) kinase, a major regulator of the cel...

Journal: :Cell 2005
Sharon E. Thomas Morvarid Soltani-Bejnood Peggy Roth Rainer Dorn John M. Logsdon Bruce D. McKee

In Drosophila males, homologous chromosomes segregate by an unusual process involving physical connections not dependent on recombination. We have identified two meiotic proteins specifically required for this process. Stromalin in Meiosis (SNM) is a divergent member of the SCC3/SA/STAG family of cohesin proteins, and Modifier of Mdg4 in Meiosis (MNM) is one of many BTB-domain proteins expresse...

2011
Jean-François Noël Raymund J. Wellinger

The fundamental process of chromosome segregation requires chromatin compaction and establishment of physical connections between sister chromatids. At the heart of these chromosome reorganizations reside three complexes formed by Structural Maintenance of Chromosome (SMC) proteins. Condensin (Smc2/4) is in charge of chromosome compaction [1] while cohesin (Smc1/3) holds together sister chromat...

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