objective(s): to investigate the efficacy of interleukin 11 (il-11) towards the high dose methotrexate (hdmtx)-concurrent rat small intestinal mucositis and its impacts on the proliferation of the human t-lymphoblastic leukemia (cem) cell line. materials and methods:95 wistar rats were randomly divided into five groups, the normal control group (a), the methotrexate (mtx) control group (b), the...

Introduction: Fuligo Plantae (FP), the ash that sticks to bottom of pots or chimneys after weeds burn, has long been used for its hemostatic effects and treatment gastrointestinal bleeding. Nevertheless, active ingredient FP still needs be further explored. Methods: The microstructure, optical chemical properties FP-CDs were characterized. An alcohol-induced gastric ulcer model was utilized eva...

BACKGROUND Perforation peritonitis is the most common surgical emergency encountered by the surgeons all over the world as well in Pakistan. The spectrum of etiology of perforation peritonitis in tropical countries continues to differ from its western counter part. This study was conducted at Dow University of health sciences and Civil Hospital Karachi (DUHS & CHK) Pakistan, designed to highlig...

Figure 2 Histopathological examination showed inflammatory granulation tissue. Kinyoun stain revealed multiple acid-fast bacilli (arrows). Culture of tissue in L wenstein-Jensen media yielded Mycobacterium tuberculosis. Intestinal tuberculosis should form part of differential diagnosis of patients presenting with lower gastrointestinal bleeding. Figure 1 A 20-year-old man with a complaint of he...

A 41-year-old man with systemic lupus erythematosus (SLE) who developed pelvic inflammation due to perforation of a giant rectal ulcer is described. The patient presented with persistent diarrhea, abdominal pain and fever without development of disease activity of SLE. Endoscopic and radiological examinations revealed a perforated giant ulcer on the posterior wall at the rectum below the perito...

BACKGROUND Approach to the small intestine has been difficult even with newer methods. Double-balloon enteroscopy (DBE) has been created for diagnostic and therapeutic interventions in diseases of the small intestine. Small intestinal diseases have different etiologies in each country. The DBE has been introduced in recent years in Iran. Our aim was to study the indications and results of DBE i...

Experimental and clinical data have incriminated excess gastric acid secretion as an important factor in the development of duodenal ulcer. On the other hand, gastric ulcer is characteristically associated with normal to low levels of acid secretion, and mucosal resistance factors have been invoked to explain the pathogenesis. The purpose of this report is to summarize the evidence favouring th...

Nonsteroidal anti-inflammatory drug (NSAID)-induced small intestinal injuries are serious clinical events and a successful therapeutic strategy is difficult. Regenerating gene (Reg) I protein functions as a regulator of cell proliferation and maintains intercellular integrity in the small intestine. The aim of this study was to evaluate the role of Reg I in NSAID-induced small intestinal injuri...

Intestinal Behçet’s Disease (BD) may manifests with several signs varying from superficial and deep ulcers to massive bleeding and colon perforation. Both mucosal ulcer and inflammation observed as a result of the affected small diameter vessels and ischemic damage findings due to the affected large diameter vessels are significantly associated with morbidity and mortality. In addition, differe...

UNLABELLED Presented case was 57-year-old male reported to be found dead in the watchman cabin in his workplace. At the autopsy, in abdominal cavity dirty green-brown colored fluid with a few particles of intestinal contents and yellow-green colored membranes on abdominal organs were observed, on the anterior wall of the rectum, 2x1.5 cm size perforation area was observed. We aimed to present t...