نتایج جستجو برای: slp

تعداد نتایج: 1597  

2015
Mark H. Ginsberg

Stimulation by chemokines of integrin α4β1–dependent T-lymphocyte adhesion is a crucial step for lymphocyte trafficking. The adaptor Vav1 is required for chemokine-activated T-cell adhesion mediated by α4β1. Conceivably, proteins associating with Vav1 could potentially modulate this adhesion. Correlating with activation by the chemokine CXCL12 of T-lymphocyte attachment to α4β1 ligands, a trans...

Journal: :Blood 2006
Annika Grabbe Jürgen Wienands

The SH2 domain-containing leukocyte adaptor protein of 65 kDa (SLP-65) is the key effector for signaling downstream of the B-cell antigen receptor (BCR). SLP-65 controls not only B lymphopoiesis and humoral immunity but also possesses a yet poorly defined tumor suppressor activity that is lost in many cases of acute lymphoblastic leukemia. We found that the 2 isoforms of human SLP-65 are differ...

Journal: :Journal of immunology 2012
Evann Corbo-Rodgers Karla R Wiehagen Elizabeth S Staub Jonathan S Maltzman

CD4(+) memory T cells are generated in response to infection or vaccination, provide protection to the host against reinfection, and persist through a combination of enhanced survival and slow homeostatic turnover. We used timed deletion of the TCR-signaling adaptor molecule Src homology 2 domain-containing phosphoprotein of 76 kDa (SLP-76) with MHC:peptide tetramers to study the requirements f...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1992
C W van den Berg P Démant P C Aerts H Van Dijk

Slp (sex-limited protein) is a mouse serum protein encoded by a major histocompatibility complex class III gene. It is considered to be a product of a duplicated complement component C4 gene, but without functional activity. Originally it has been found expressed only in adult males with the S region of the H-2d or H-2s haplotype. In this report we present evidence that Slp is involved in a for...

Journal: :Journal of immunology 2003
Xiao-Ping Zhong Jonathan S Maltzman Ehmonie A Hainey Gary A Koretzky

SLP-76 (Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa) is an adaptor molecule expressed in all hemopoietic cell lineages except mature B cells and is known to play critical roles in the function of T cells, mast cells, and platelets and in vascular differentiation. Although great progress has been achieved in our understanding of SLP-76 function, little is known about the ...

2004
Sheng-Gang Li

The aim of this paper is to establish some Cartesian closed categories which are between the two Cartesian closed categories: SLP (the category of L-domains and stable functions) and DI (the full subcategory of SLP whose objects are all dI-domains). First we show that the exponentials of every full subcategory of SLP are exactly the spaces of stable functions. Then we prove that the full subcat...

Journal: :Cell 1998
Vadim Pivniouk Erdyni Tsitsikov Paul Swinton Gary Rathbun Frederick W Alt Raif S Geha

The adaptor protein SLP-76 is expressed in T lymphocytes and myeloid cells and is a substrate for ZAP-70 and Syk. We generated a SLP-76 null mutation in mice by homologous recombination in embryonic stem cells to evaluate the role of SLP-76 in T cell development and activation. SLP-76-deficient mice exhibited subcutaneous and intraperitoneal hemorrhaging and impaired viability. Analysis of lymp...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1982
D R Karp K L Parker D C Shreffler C Slaughter J D Capra

Limited primary sequence data have been obtained for all three subunits of the fourth component of murine complement (C4) and its related homologue, the sex-limited protein (Slp). These data show a high degree of NH2-terminal homology between C4 and Slp: four of the six residues identified for the alpha chain, seven of eight for the beta chain, and four of four for the gamma chain. This suggest...

2017
Panagiotis Mitsopoulos Orsolya Lapohos Woranontee Weraarpachai Hana Antonicka Yu-Han Chang Joaquín Madrenas

Mitochondria translate the RNAs for 13 core polypeptides of respiratory chain and ATP synthase complexes that are essential for the assembly and function of these complexes. This process occurs in close proximity to the mitochondrial inner membrane. However, the mechanisms and molecular machinery involved in mitochondrial translation are not fully understood, and defects in this process can res...

2015
Ana Dios-Esponera Soledad Isern de Val Silvia Sevilla-Movilla Rosa García-Verdugo David García-Bernal Nohemí Arellano-Sánchez Carlos Cabañas Joaquin Teixidó Mark H. Ginsberg

Stimulation by chemokines of integrin α4β1-dependent T-lymphocyte adhesion is a crucial step for lymphocyte trafficking. The adaptor Vav1 is required for chemokine-activated T-cell adhesion mediated by α4β1. Conceivably, proteins associating with Vav1 could potentially modulate this adhesion. Correlating with activation by the chemokine CXCL12 of T-lymphocyte attachment to α4β1 ligands, a trans...

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