objective(s) isoniazid (inh) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. resistance to inh is mediated mainly by mutation in katg gene that is coded for the catalase enzyme. the proportional method for detection of inh-resistance is time consuming due to the slow...

BACKGROUND AND OBJECTIVES Current tools struggle to detect drug-resistant malaria parasites when infections contain multiple parasite clones, which is the norm in high transmission settings in Africa. Our aim was to develop and apply an approach for detecting resistance that overcomes the challenges of polyclonal infections without requiring a genetic marker for resistance. METHODOLOGY Clinic...

Despite full voluntary effort, neuromuscular activation of the quadriceps femoris muscle appears inhibited during slow concentric and eccentric contractions. Our aim was to compare neuromuscular activation during maximal voluntary concentric and eccentric quadriceps contractions, hypothesizing that inhibition of neuromuscular activation diminishes with resistance training. In 15 men, pretrainin...

Efforts to advance environmental justice are often halting and uneven. How can we identify the longer-term significance of protests that seem have failed? In this article, turn work on injustice examine consequences movements over time across space. We draw scholarship Rob Nixon ‘slow violence’: rather than spectacular, visceral, immediate violence war, he argues degradation is a operates in cu...

In the slow-wave (SW) state, the vast majority of cortical neurons exhibit mostly synchronized oscillatory activity. In this study, we examined the right-left hemispheric difference in slow-wave timings in urethane-anesthetized mice. We found that interhemispheric cross-correlograms of local field potentials (LFPs) peaked asymmetrically. Double in vivo whole-cell patch-clamp recordings also rev...

To gain further insight into the mechanisms underlying muscle insulin resistance, the influence of obesity and type 2 diabetes on GLUT4 immunoreactivity in slow and fast skeletal muscle fibers was studied. Through a newly developed, very sensitive method using immunohistochemistry combined with morphometry, GLUT4 density was found to be significantly higher in slow compared with fast fibers in ...

A micro-addition (0.025 at.%) of slow-diffusing W to an Al-0.26Mn-0.11Mo-0.11Si-0.08Zr-0.02Sc-0.01Er (at.%) alloy accelerates L12-Al3(Zr,Sc) precipitation but retards ?-Al(Mn,Mo)Si precipitation. The increases the peak-microhardness during isothermal aging does not improve coarsening resistance and creep resistance.

Neuronal population oscillations at a variety of frequencies can be readily seen in electroencephalographic (EEG) as well as local field potential recordings in many different species. Although these brain rhythms have been studied for many years, the methods for identifying discrete oscillatory epochs are still widely variable across studies. The "better oscillation detection" (BOSC) method ap...