نتایج جستجو برای: slim tube
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Spatial light interference microscopy (SLIM) is a highly sensitive quantitative phase imaging method, which is capable of unprecedented structure studies in biology and beyond. In addition to the π/2 shift introduced in phase contrast between the scattered and unscattered light from the sample, 4 phase shifts are generated in SLIM, by increments of π/2 using a reflective liquid crystal phase mo...
In this paper we present the Slim-tree, a dynamic tree for organizing metric datasets in pages of fixed size. The Slim-tree uses the "fat-factor" which provides a simple way to quantify the degree of overlap between the nodes in a metric tree. It is well-known that the degree of overlap directly affects the query performance of index structures. There are many suggestions to reduce overlap in m...
Increasingly, communication requires more from the network stack. Due to missing functionality, we see a proliferation of networking libraries that attempt to fill the void (e.g., iOS to OSX Handoff and Google Cast SDK). This leads to considerable duplication of effort. Further, the provisions for extending legacy protocol stacks is largely exhausted (e.g., TCP options space is mostly allocated...
Lysosome Associated Protein Transmembrane 4B (LAPTM4B) is a four-membrane spanning ceramide interacting protein that regulates mTORC1 signaling. Here, we show LAPTM4B sorted into intraluminal vesicles (ILVs) of multivesicular endosomes (MVEs) and released in small extracellular (sEVs) conditioned cell culture medium human urine. Efficient sorting ILV membranes depends on its third transmembrane...
Protein-protein interactions through short linear motifs (SLiMs) are an emerging concept that is different from interactions between globular domains. The SLiMs encode a functional interaction interface in a short (three to ten residues) poorly conserved sequence. This characteristic makes them much more likely to arise/disappear spontaneously via mutations, and they may be more evolutionarily ...
INTRODUCTION Considering a lack of efficacy data in patients with early rheumatoid arthritis (eRA) presenting without classical markers of poor prognosis, we compared methotrexate (MTX) with or without step-down glucocorticoids in the CareRA trial. METHODS Disease-modifying antirheumatic drug-naïve patients with eRA were stratified into a low-risk group based on prognostic markers that includ...
The subjective likelihood model [SLiM; McClelland, J. L., & Chappell, M. (1998). Familiarity breeds differentiation: a subjective-likelihood approach to the effects of experience in recognition memory. Psychological Review, 105(4), 734– 760.] and the retrieving effectively from memory model [REM; Shiffrin, R. M., & Steyvers, M. (1997). A model for recognition memory: REM—Retrieving effectively ...
Short linear motifs (SLiMs) in proteins are self-sufficient functional sequences that specify interaction sites for other molecules and thus mediate a multitude of functions. Computational, as well as experimental biological research would significantly benefit, if SLiMs in proteins could be correctly predicted de novo with high sensitivity. However, de novo SLiM prediction is a difficult compu...
Due to their diameter, of only 24 nm, single microtubules are extremely challenging to image without the use of extrinsic contrast agents. As a result, fluorescence tagging is the common method to visualize their motility. However, such investigation is limited by photobleaching and phototoxicity. We experimentally demonstrate the capability of combining label-free spatial light interference mi...
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