A 22-year-old female patient presented to the Emergency Department of a tertiary care hospital with symptoms of headache and nausea. She has been on a regular follow-up for the preceding three and a half years after being diagnosed as systemic lupus erythematosus (SLE). She had been treated earlier for SLE nephritis in the same institution, and had two relapses of nephrotic syndrome in the last...

The purpose of this note is to describe a framework which unifies radial, chordal and dipolar SLE. When the definition of SLE(κ; ρ) is extended to the setting where the force points can be in the interior of the domain, radial SLE(κ) becomes chordal SLE(κ; ρ), with ρ = κ − 6, and vice versa. We also write down the martingales describing the Radon-Nykodim derivative of SLE(κ; ρ1, . . . , ρn) wit...

Neutropenia is a common laboratory finding in systemic lupus erythematosus (SLE). However, the molecular mechanism of SLE neutropenia has not been fully explained. In this study, we examined whether TNF-related apoptosis-inducing ligand (TRAIL) is involved in the pathogenesis of SLE neutropenia using samples from SLE patients. Serum TRAIL levels in SLE patients with neutropenia were significant...

Systemic lupus erythematosus (SLE) is a risk factor for hypertension. Previously, we demonstrated that an established mouse model of SLE (female NZBWF1 mice) develops hypertension with renal inflammation and oxidative stress, both characteristics known as contributing mechanisms to the development of salt-sensitive hypertension. On the basis of this model, we hypothesized that blood pressure in...

PURPOSE To distinguish lupus flare-up from infection in systemic lupus erythematosus (SLE), we analyze the expression of circulating CD27(high) plasma cells in SLE patients with and without infection, in comparison to non-SLE patients with infection. MATERIALS AND METHODS The percentage of circulating CD27(high) plasma cells was measured by flow cytometry in the following four groups: 36 SLE ...

OBJECTIVE Accelerated atherosclerosis is a major source of morbidity in systemic lupus erythematosus (SLE). However, the cause of SLE-accelerated atherosclerosis remains unclear. METHODS CD4(+) T cells from C57/Bl/6 (B6) or SLE-susceptible B6.Sle1.2.3 (B6.SLE) mice were transferred into LDLr(-/-), Rag(-/-) mice. T cells were examined for cytokine production and expression of interleukin-10 re...

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disorder with a high prevalence of hypertension and cardiovascular disease. Because SLE predominantly affects women, estrogen is commonly implicated as a contributor to SLE disease progression. Using an established mouse model of SLE (female NZBWF1), we tested whether estrogen has a causal role in the development of hyperte...

The purpose of this note is to describe a framework which unifies radial, chordal and dipolar SLE. When the definition of SLE(κ; ρ) is extended to the setting where the force points can be in the interior of the domain, radial SLE(κ) becomes chordal SLE(κ; ρ), with ρ = κ− 6, and vice versa. We also write down the martingales describing the Radon–Nykodim derivative of SLE(κ; ρ1, . . . , ρn) with...

OBJECTIVE Whether using provider-attributed end-stage renal disease (ESRD) cause of systemic lupus erythematosus (SLE) in national surveillance data captures the entire population of patients with SLE and ESRD remains uncertain. Our goal was to examine attributed cause of ESRD in US surveillance data among patients with SLE who have developed ESRD. METHODS Data from a national registry of tre...