BACKGROUND Skin grafting is a relatively simple and thus widely used procedure. However, the elastic and structural quality of grafted skin is poor. Recently, various dermal substitutes have been developed to overcome this disadvantage of split-thickness skin grafts. The present study aims to determine the feasibility of RapiGraft as a new dermal substitute. METHODS This prospective study inc...

During a meningococcal outbreak, 221 patients were studied. A skin rash was present in 78 (35.3%) patients. Twenty one (11.3%) patients had a frankly purpuric rash, involving mainly the extremities and the remaining had a generalised macular or petechial lesions. Extensive purpuric lesions, involving mainly the extremities were associated with disseminated intravascular coagulation (DIC), shock...

George B Mair (Aberdeen, Scotland) has used whole Skin grafts as a substitute for fascial And other structure in the plastic repair of hernias. He has reported that no late postoperative complication have occured. After implantation of grafts in rabbits sections were examined at intervals up to 10 months. It was found that hiar follicles and sweet glands had disappeared. The grafts were gradual...

PVA foam has been used as a temporary skin substitute since 1977. PVA is a white, monolayered, microporous sponge. In animal experiments it was shown that cell detritus, fibrin-fur and microorganisms were taken in and kept inside the material. This effectively cleans the wound surface, the so-called “microdebridement” process. The effect is due to a strong adherence and a high capacity to absor...

OBJECTIVE Deliberate self-harm resulting in extensive skin scarring is a difficult clinical problem and is commonly associated with physical and sexual abuse or a known history of mental illness. Immediate hospital attendance often addresses the acute wound and current psychological state of patients; however, ongoing regret of these resulting scars present a problem to the patient and clinicia...

BACKGROUND The treatment of severe full-thickness skin defects represents a significant and common clinical problem worldwide. A bio-engineered autologous skin substitute would significantly reduce the problems observed with today's gold standard. METHODS Within 15 years of research, the Tissue Biology Research Unit of the University Children's Hospital Zurich has developed autologous tissue-...

In the present study, chitosan membranes capable of imitating permeation characteristics of diclofenac diethylamine across animal skin were prepared using cast drying method. The effect of concentration of chitosan, concentration of cross-linking agent (NaTPP), crosslinking time was studied using Taguchi design. Taguchi design ranked concentration of chitosan as the most important factor influe...

The primary function of the skin is to act as a barrier against unwanted influences from the environment. The barrier function of the skin is located in the superficial of the skin, the stratum corneum. The stratum corneum consists of dead cells filled with keratin and water, which are embedded in lipid regions. The lipid regions are the only continuous structure in the stratum corneum. For thi...

INTRODUCTION Pressure ulcers represent a significant cause of morbidity and health care expenditure in the United States. A pressure ulcer is a lesion of localized injury to the skin or underlying tissue, usually over a bony prominence, resulting from pressure alone or in combination with shear forces. Ulcers are staged based on depth of tissue involvement. Using the revised National Pressure U...

Ondansetron HCl delivery through oral route suffers due to its low bioavailability due to first-pass metabolism. Therefore, the microemulsion-based transdermal delivery may be a better substitute for it. The pseudoternary phase diagrams were constructed to determine compositions of microemulsions, and ondansetron HCl microemulsions for transdermal delivery were developed using isopropyl myrista...