A skin permeability barrier is essential for terrestrial animals, and its impairment causes several cutaneous disorders such as ichthyosis and atopic dermatitis. Although acylceramide is an important lipid for the skin permeability barrier, details of its production have yet to be determined, leaving the molecular mechanism of skin permeability barrier formation unclear. Here we identified the ...

There is considerable interest in the skin as a site of anti-cancer drug application. Nevertheless, the skin poses a formidable barrier to drug penetration, thereby limiting topical and transdermal bioavailability. However, we previously showed that a thioglycolate-based depilatory agent increases the drug permeability of mouse skin. In the present report, we investigated the skin permeability ...

Permeability reduction in oil reservoirs during primary oil recovery and using the enhanced oil recovery methods are complicated problem which most of the oil field in worlds has encountered. In this work, a modified model based on four phase black oil model (oil, water, gas, and asphaltene) was developed to account permeability reduction during CO2 flooding in cylindrical coordinates around a ...

Our previous study revealed that newborns had a high level of absorption of human milk a-lactalbumin. [1] It decreased during the first month in the whole and nonallergic infants showed a 4fold reduction of gut permeability at 25-30 days of life. But patients with early allergic symptoms have increased gut permeability in comparison to non-allergic infants. In this study we examined gut permeab...

Collagen pentapeptide (Lys-Thr-Thr-Lys-Ser, KTTKS) and its palmitoylated derivative (pal-KTTKS) have received a great deal of attention as cosmeceutical ingredients for their anti-wrinkle effects. The objective of this study was to evaluate stability and permeability of KTTKS and pal-KTTKS in hairless mouse skin. In this study, a liquid chromatography-tandem mass spectrometric method was develo...

The aim of the present study was to investigate the relationship between the polar surface area and other molecular properties of the model drugs and their transdermal permeability across the rat skin. Few model drugs which are weakly acidic (ibuprofen, aceclofenac and glipizide) and weakly basic (olanzapine, telmisartan and sildenafil citrate) were selected for the study based on Polar surface...