The purpose of this study was to enhance the existing time dependent flux model for the transdermal iontophoretic transport of drugs. This study evaluated the flux data as influenced by time and current density. In vitro iontophoresis performed on the piglet (Sus scrofa) necropsy–taken medial scapha pinneal skin that mounted in the U shaped sink chamber. Iontophoresis of atenolol with a constan...

The aim of this study was to determine the specific agent responsible for eczema on the forearms of 2 electronic assemblers who cleaned out a flux-spraying unit once a week. Soldering flux can be a source of skin irritation as well as allergy. Patch test with dried flux residue (as is) and rosin in dilution series of 20%, 10%, and 1% in olive oil was performed. Readings were taken on day 2 and ...

Transdermal drug delivery has many potential advantages, but the skin's poorly-permeable stratum corneum blocks delivery of most drugs at therapeutic levels. Short high-voltage pulses have been used to electroporate the skin's lipid bilayer barriers and thereby deliver compounds at rates increased by as much as four orders of magnitude. Evidence that the observed flux enhancement is due to phys...

A reservoir type transdermal patch for delivery of ketorolac, a potent analgesic agent was studied. The low permeability of skin is the rate-limiting step for delivery of most of the drugs. Studies were carried out to investigate the effect of permeation enhancers on the in vitro permeation of ketorolac across rat skin. The reservoir type transdermal patch was fabricated and the core was filled...

Skin-surface cooling elicits a pronounced systemic pressor response, which has previously been reported to be associated with peripheral vasoconstriction and may not fully account for the decrease in systemic vascular conductance. To test the hypothesis that whole body skin-surface cooling would also induce renal and splanchnic vasoconstriction, 14 supine subjects performed 26 skin-surface cool...

The objective of the present work is to correlate the timedependent flow characteristics of cryogen sprays to the induced thermal dynamics at the surface of a human skin model. First, a numerical analysis to evaluate our skin model is carried out. Next, diameter and axial velocity of droplets impinging onto the skin model are measured. Diameter, velocity and surface temperature are acquired sim...

lisinopril dihydrate (angiotensin converting enzyme inhibitor) is a lysine derivative of enalaprilat and does not require hydrolysis to exert pharmacological activity. it has an extensive hepatic first pass metabolism resulting in a bioavailabil-ity of 6-60%. to overcome the poor bioavailability of the drug, transdermal patches have been prepared. the present study also aims at optimization of ...

results the mean kt/v was 1.27 ± 0.28 in high-flux and 1.10 ± 0.32 in low-flux membrane which, these differences were statistically significant (p = 0.017). the mean of urr was 0.65 ± 0.09 in high-flux and 0.61 ± 0.14 in low-flux membrane, which these differences were not statistically significant (p = 0.221). patients and methods forty hemodialysis patients participated in this cross-over clin...