BACKGROUND Skin flaps are commonly used in soft-tissue reconstruction; however, necrosis can be a frequent complication. Several systemic and local agents have been used in attempts to improve skin flap survival, but none that can prevent flap necrosis have been identified. AIMS This study aims to determine whether the use of systemic Rosmarinus officinalis (R. officinalis) extract can preven...

Despite all modern surgical techniques, skin flap that is considered as the main method in most reconstructive surgeries puts the skin tissue at danger of necrosis and apoptosis derived from ischemia. Therefore, finding a treatment for decreasing the apoptosis derived from flap ischemia will be useful in clinic. In present study, we evaluated the effect of azelaic acid 20% and finasteride on ex...

OBJECTIVE The purpose of this study is to determine the correlation between non-technical risk factors and the perioperative flap survival rate and to evaluate the choice of skin flap for the reconstruction of foot and ankle. METHODS This was a clinical retrospective study. Nine variables were identified. The Kaplan-Meier method coupled with a log-rank test and a Cox regression model was used...

The number of breast reconstruction procedures has been increasing in recent years. One of the suggested treatment methods is breast reconstruction with a pedicled skin and muscle TRAM flap (transverse rectus abdominis muscle - TRAM). Surgical incisions performed during a cholecystectomy procedure may be located in the areas significant for flap survival. The aim of this paper is to present ana...

BACKGROUND Sensory recovery of skin flaps is generally poor unless they are elevated as an innervated flap. The aim of this study was to elucidate if Schwann cell (SC)-like cells differentiated from adipose-derived stem cells (ASCs) could improve the cutaneous nerve regeneration in skin flaps. METHODS Microvascular island groin flaps were elevated bilaterally in 32 Lewis rats. On the right fl...

INTRODUCTION The understanding of the skin's vascular anatomy has improved in the last decade. It has lead to technique modification such as the staged procedure in performing sural flaps and improvement in the flap survival rate. The aim of this study was to evaluate the acute vascular complications (flap necrosis or congestion) of 29 patients who underwent distal base sural flap for coverage ...

two patients with penile skin loss who were operated in 1991 are reviewed retrospectively. in both of them skin grafting was mandatory (due to large skin defects on the penile shaft). causative factors were localized infection in one case and verrucae accuminata in another. in both cases a random flap from the skin of the inner surface of the thigh was applied. the pedicle flap was later transe...

Indocyanine green (ICG) fluorography which is used to visualize the arteries, veins, and lymphatic vessels through the skin surface has recently been developed. This article includes an overview of our clinical experiences as well as descriptions of the latest knowledge on the utilization of ICG fluorography in the fields of plastic surgery and microvascular surgery. Imaging of the Capillary Bl...

BACKGROUND AIMS The aim of this study was to investigate the effects of low-level light therapy (LLLT) on transplanted human adipose-derived mesenchymal stromal cells (ASCs) in the skin flap of mice. METHODS LLLT, ASC transplantation and ASC transplantation with LLLT (ASC + LLLT) were applied to the skin flap. Immunostaining and Western blot analysis were performed to evaluate cell survival a...