Cancer chemopreventive effects of polyphenols from green tea (GTP) in mouse models of photocarcinogenesis are established. The present study is extended from mouse model to human system in vivo to determine the effect of topical application of GTP to human individuals against UV light-induced DNA damage in the form of cyclobutane pyrimidine dimers (CPDs) in the skin. UVB-induced CPDs were detec...

Introduction Radiation therapy is crucial to effective cancer treatment. Modern treatment strategies have reduced possible skin injury, but few clinical studies have addressed the dose relationship between radiation exposure and skin reaction. This prospective clinical study analyzes skin oxygenation/perfusion in patients undergoing fractionated breast conserving therapy via hyperspectral imagi...

Background and Purpose: Moist Desquamation (MD) is a concerning acute side effect of radiation therapy for breast cancer, often seen in skin folds patients having large or pendulous breasts. In-vivo dosimetry, clinical assessments patient reported reactions were used to determine relationship between dose-area metrics the development MD, lend insight into tolerances possibly guide future treatm...

BACKGROUND Tuberculosis remains a serious disease worldwide. Anti-tuberculosis campaigners many times face negative tuberculin skin tests after Bacille Calmette Guérin vaccination. Increasing tuberculin units might be a solution. However, is skin reaction a linear function of tuberculin dose? Are there any side-effects when higher tuberculin doses are administered? CASE PRESENTATION Six simul...

Abstract Advocates of skin protection against blue light express concern about exposure to indoor lighting and electronic screens as well natural outdoor exposure. However, the nature adverse effects in is unclear doses induce are unknown. We aimed reveal whether there a scientific basis for promoting violet-blue (400–500 nm, VBL). Based on published literature, we determined time reach thresho...

As a novel heat shock protein 90 inhibitor, AT-533 exhibits various biological activities in vitro, including anti-viral, anti-tumor and anti-inflammatory activities. Moreover, gel, gel dosage form of AT-533, has been suggested to have anti-keratitis herpes simplex virus type-1 infection-induced effects on the skin lesions animals. However, safety evaluation has, best our knowledge, not examine...

Background: To reduce the dose to normal tissues surrounding the treated breast, a uniform magnetic field was used within a humanoid phantom in breast radiotherapy. Materials and Methods: Monte Carlo simulations were performed with GEANT4, irradiating humanoid phantoms in a magnetic field. To reconstruct phantoms, computed tomography (CT) data slices of four patients were used for the Monte Car...