نتایج جستجو برای: skf 38393

تعداد نتایج: 1014  

Journal: :Indian journal of physiology and pharmacology 1996
J Singh T Desiraju T R Raju

The experimental animals were implanted with two bipolar electodes, one in the lateral hypothalamus including medial forebrain bundle (LH-MFB) and other in ipsilateral ventral tegmental area-substantia nigra (VTA-SN) and were trained to press a pedal for self-stimulation. This provided the scope to compare directly the effect of a given dose of a drug on the two reward regions in the same anima...

Journal: :Journal of neurophysiology 2002
David N Ruskin Debra A Bergstrom Judith R Walters

Altered activity of the entopeduncular nucleus, the rodent homologue of the globus pallidus internal segment in primates, is thought to mediate behavioral consequences of midbrain dopamine depletion in rodents. Few studies, however, have examined dopaminergic modulation of spiking activity in this nucleus. This study characterizes changes in entopeduncular neuronal activity after nigrostriatal ...

پایان نامه :وزارت بهداشت، درمان و آموزش پزشکی - دانشگاه علوم پزشکی و خدمات بهداشتی درمانی تهران 1370

چکیده تاثیر آگونیستهای دوپامین بردمای داخلی بدن موش سوری، موردآزمایش قرارگرفته است ونتایج زیربدست آمده اند :- 1 آپومرفین بصورت وابسته به دوز، دمای بدن موش راکاهش میدهد.این پاسخ بوسی آنتاگونیست گیرنده d2، سولپیراید،مهارشده است ولی sch 23390،آنتاگونیست گیرنده d1،اثری روی هیپوترمی ناشی از آپومرفین نداشته است .- 2 تجویز quinpirole،آگونیست گیرنده d2،نیز سبب هیپوترمی میگردد وسولپیرای جلوی این اثر رام...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1993
S L Vincent Y Khan F M Benes

The relative distribution and cellular localization of the dopamine D1 and D2 receptor subtypes were assessed in frozen sections of rat medial prefrontal cortex (mPFC). The D1 and D2 receptor binding sites were labeled with the selective high-affinity antagonists SCH 23390 and N-(p-aminophenethyl)-spiperone (NAPS), respectively, coupled to either Bodipy or Texas red fluorophores. Under the incu...

2013
Frederick E. Albrecht John Drago Robin A. Felder Morton P. Printz Gilbert M. Eisner Jean E. Robillard David R. Sibley Heiner J. Westphal Pedro A. Jose

Since dopamine produced by the kidney is an intrarenal regulator of sodium transport, an abnormality of the dopaminergic system may be important in the pathogenesis of hypertension. In the spontaneously hypertensive rat (SHR), in spite of normal renal production of dopamine and receptor density, there is defective transduction of the D 1 receptor signal in renal proximal tubules, resulting in d...

Journal: :The Journal of clinical investigation 1996
F E Albrecht J Drago R A Felder M P Printz G M Eisner J E Robillard D R Sibley H J Westphal P A Jose

Since dopamine produced by the kidney is an intrarenal regulator of sodium transport, an abnormality of the dopaminergic system may be important in the pathogenesis of hypertension. In the spontaneously hypertensive rat (SHR), in spite of normal renal production of dopamine and receptor density, there is defective transduction of the D1 receptor signal in renal proximal tubules, resulting in de...

2014
Karina Possa Abrahao Francine Oliveira Goeldner Maria Lucia Oliveira Souza-Formigoni

In mice there are clear individual differences in the development of behavioral sensitization to ethanol, a progressive potentiation of its psychomotor stimulant effect. Variability in the behavioral responses to ethanol has been associated with alcohol preference. Here we investigated if the functional hyperresponsiveness of D1 receptors observed in ethanol sensitized mice leads to an increase...

Abbas Haghparast, Afsaneh Elyasi, Zahra Mirmohammadsadeghi,

Introduction: Dopamine plays an important role in the central nervous system for modulating food intake. Dopamine receptors are distributed within the hypothalamus, and expression of D1 receptors is significant in hypothalamic paraventricular nucleus (PVN). Therefore, the aim of this study was to find if PVN-microinjected SKF38393, D1 receptor agonist, may modulate food intake. Methods: Gui...

Journal: :The Journal of clinical investigation 1989
S Kinoshita A Sidhu R A Felder

The natriuretic effect of DA-1 agonists is less in the spontaneously hypertensive rat (SHR) than its normotensive control, the Wistar-Kyoto rat (WKY). To determine a mechanism of the decreased effect of DA-1 agonists on sodium transport, DA-1 receptors in renal proximal convoluted tubule (PCT) were studied by radioligand binding and by adenylate cyclase (AC) determinations. Specific binding of ...

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