Thymic selection is a tightly regulated developmental process essential for establishing central tolerance. The intensity of TCR-mediated signaling is a key factor for determining cell fate in the thymus. It is widely accepted that low-intensity signals result in positive selection, whereas high-intensity signals induce negative selection. Transmembrane adaptor proteins have been demonstrated t...

BACKGROUND Too much prolonged sitting is a prevalent health risk among adults. Interventions have focused mainly on the workplace, with limited attention to non-work settings. The effectiveness of a short-term intervention to reduce and break-up sitting-time in overweight/obese adults was examined. This pilot study sought to determine the feasibility of interrupting sitting to stand/ambulate ob...

BACKGROUND The study tests the hypothesis of a reduction of priming due to tree allergy in patients sensitised to both birch/hazel and grass pollen undergoing an associated preseasonal Sublingual/Injective immunotherapy. METHODS 36 out of 49 bisensitized candidates were pair-matched into 18 case-referent couples. During two years all patients were administered preseasonal grass-SIT and one pa...

INTRODUCTION The association of situs inversus totalis (SIT) and VACTERL syndrome an extremely rare coincidence. PATIENTS The patient was first diagnosed as simple SIT with lumbosacral neoplasms according to the prenatal magnetic resonance imaging (MRI) examination; however, the local hospital ignored the important to physical examination so that missed anal atresia with fistula. The patient ...

BACKGROUND AND PURPOSE Performing nontraditional abdominal exercises with devices such as abdominal straps, the Power Wheel, and the Ab Revolutionizer has been suggested as a way to activate abdominal and extraneous (nonabdominal) musculature as effectively as more traditional abdominal exercises, such as the crunch and bent-knee sit-up. The purpose of this study was to test the effectiveness o...

OBJECTIVE To compare an objective assessment scale for "come-to-sit" in stroke patients with the previously established subjective assessment scales of "performance-based assessment" and the "ability for basic movement scale". METHOD A specifically designed jacket was used to determine the objective degree of assistance needed for patients to perform the task. While patients were sitting up, ...

We estimate two essential sea ice parameters—namely, sea ice concentration (SIC) and sea ice thickness (SIT)—for the Bohai Sea using a combination of a thermodynamic sea ice model and Earth observation (EO) data from synthetic aperture radar (SAR) and microwave radiometer. We compare the SIC and SIT estimation results with in-situ measurements conducted in the study area and estimates based on ...

BACKGROUND Allergen-specific immunotherapy (SIT) has been used since 1911, yet its mechanism of action remains to be elucidated. There is evidence indicating that CD4(+)FOXP3(+) regulatory T cells (Treg cells) are induced during SIT in allergic patients. However, the contribution of these cells to SIT has not been evaluated in vivo. OBJECTIVE To evaluate the in vivo contribution of (i) CD4(+)...

Purpose: To assess physical fitness, gross motor capacity, and their relationship in children with neurofibromatosis type 1 (NF1). 
 Materials Methods: Children NF1 (n=40, age 6-17, mean 9.70±3.8 years) typically developing (TDC) (n= 28, 5,5-17,5, 11.35±3.0 were evaluated by the six-minute walking test, sit-up sit-and-reach flamingo balance test body mass index. Gross capacity was assessed...

Depression is a general public health problem; there is an association between regular exercise or vigorous physical activity and depression. Physical activity has positive physical, mental, and emotional effects. The purpose of this study was to examine the relationship between depression symptom and physical performance in elderly women. A total of 173 elderly women aged 65 to 80 participated...