Targeted delivery of drugs to colon has the potential for local treatment of a variety of colonic diseases. The main objective of the study was to develop a multiparticulate system containing chitosan microspheres for the colon targeted delivery of ondansetron for the treatment of irritable bowel syndrome. This work combines pH-dependent solubility of eudragit S-100 polymers and microbial degra...

Gastro-colic fistulas as a complication of benign gastric ulcers are relatively uncommon. The authors report a 59 year old caucasian female with a known hiatus hernia and gastro-oesophageal reflux disease presenting with diarrhoea and weight loss. Barium enema is the investigation of choice although it is important to exclude malignancy. Management is by en-bloc resection of the fistula with pr...

BACKGROUND There is a high prevalence of gastro-duodenal disease in sub-Saharan Africa. Peptic ulcer disease in dyspeptic patients, 24.5%, was comparable to prevalence of gastro-duodenal disease among symptomatic individuals in developed countries (12 - 25%). Limited data exists regarding its associated risk factors despite accumulating evidence indicating that gastroduodenal disease is common ...

UNLABELLED ᅟ: Listeria monocytogenes is a food-borne pathogen and the causative agent of listeriosis, a severe infection to those with a pre-disposition. Infections often arise through consumption of contaminated foods, where high intrinsic resistance to food processing practises permit survival and growth. Several practises, including refrigeration, acidification and oxygen limitation are inef...

Losso organspecific antigens has been shown to occur in epperimental and human carcinomas The present investigation, by serological and immunofluorescence methods, of a gastro-intestinal-specific antigen (Nairn et al., 1961; Nairn, 1962b) in human gastro-intestinal neoplasia demonstrates that loss of antigen is a feature of colonic and gastric carcinomas. Lesser degrees of depletion are found i...

Authors report the available scientific evidence on the role of proton pump inhibitors and upper gastro-intestinal endoscopy in the management of patients with gastro-oesophageal reflux disease. Relative indications, advantages and pitfalls of various diagnostic and therapeutic strategies for cost-effective management of this condition are discussed. The most recent evidence-based guidelines ar...

celiac disease can be accompanied with multiorgan involvement in addition to gastro-intestinal involvement. a 16-year-old young man - known case of celiac disease - was admitted because of exacerbation of gastrointestinal complaints. during further investigations, hypothyroidism and membranous glomerulonephritis were discovered. the patient was improved with a gluten-free diet and specific trea...

Background: Gastro-intestinal anastomosis is mostly performed to correct the gastro-intestinal surgical disorders like obstruction, abdominal trauma, perforated bowel, intussusception and intestinal neoplasia etc. In early periods conventional was followed which evolved into a seromuscular pattern of suture technique in recent years. Stapled have higher tensile strength than sutured anastomosis...

THis useful manual contains a description of endoscopy as it applies to gastroenterology. There are a few black and white figures, largely to illustrate technical procedure but none to illustrate the appearances seen, and in this respect it is severly lacking. But ,as a resum6 of a subject which is beginning to be of increasing importance it provides a good introduction. The author speaks from ...