Background: In the last decades, mesoporous silica nanoparticles (MSN) are improved for drug delivery, imaging, and biomedical applications due to their special properties such as large surface area, high drug loading capacity, tunable pore size, and modification of surface area by functional groups. Objectives: The aim of this study was to evaluate MSNs as carriers for oral colon-specific and...

A promising strategy for finding new cancer drugs is to use metabolic network models to investigate the essential reactions or genes in cancer cells. In this study, we present a generic constraint-based model of cancer metabolism, which is able to successfully predict the metabolic phenotypes of cancer cells. This model is reconstructed by collecting the available data on tumor suppressor genes...

Hepatitis B virus (HBV) infection commonly occurs through horizontal transmission via household/close contact. Although the body fluids of patients infected with HBV are likely to play a significant role in horizontal transmission, the precise mechanism remains unclear. In the 1970s, the infectivity of body fluids including saliva, urine, and faeces was assessed for the presence of hepatitis B ...

A new composite of poly(methyl methacrylate) – co -(ethyl-hexyl-acrylate) filled with glass of composition (wt.%) 61,33% 3CaO.P2O5 23,03% SiO2 – 15,64% MgO was developed. The formation of CaP (calcium phosphate) layers on implants is crucial for their integration in bone. Simulated biological fluids to study in vitro formation of those layers do not usually contain important organic substances,...

background: health care workers are facing certain occupational hazards because of sharp injury and exposure to human blood and body fluids as a result of handling wastes. though much attention is paid for the protection of these workers, the number of exposures and injuries do not show a sign of decline from time to time. objective: to examine the occurrence of sharp injury and exposure to blo...