OBJECTIVE Statins are widely used lipid-lowering drugs, which have pleiotropic effects, such as anti-inflammation, and vascular protection. In our study, we investigated the radioprotective potential of simvastatin (SIM) in a murine model of radiation-induced salivary gland dysfunction. DESIGN Ninety-six Institute of Cancer Research mice were randomly divided into four groups: solvent + sham ...

The single-minded (sim) gene encodes a transcriptional regulator that functions as a key determinant of central nervous system (CNS) midline development in Drosophila. We report here the identification of two murine homologs of sim, Sim1 and Sim2, whose products show a high degree of sequence conservation with Drosophila SIM in their amino-terminal halves, with each containing a basic helix-loo...

By combining SIM observations with ground-based photometry, one can completely solve microlensing events seen toward the Galactic bulge. One could measure the mass, distance, and transverse velocity of ∼ 100 lenses to ∼ 5% precision in only ∼ 500 hours of SIM time. Among the numerous applications are 1) measurement of the mass functions (MFs) of the bulge and disk 2) measurement of the relative...

We describe the WebSIM, an approach that integrates GSM SIMs into the Internet. The underlying idea is to implement a Web Server inside a SIM, and to allow for transparent access to it from the Internet. The contribution of our approach is that a SIM, which is currently a security module (smart card) fitted in a GSM mobile phone, becomes also a personal security server in the Internet. Like any...

This document specifies an Extensible Authentication Protocol (EAP) mechanism for authentication and session key distribution using the GSM Subscriber Identity Module (SIM). The mechanism specifies enhancements to GSM authentication and key agreement whereby multiple authentication triplets can be combined to create authentication responses and encryption keys of greater strength than the indiv...

Professors Jerry Luftman and Eph McLean, long-time SIM Executive Board members, conducted an issues survey of our membership and compared it to other SIM and conference board surveys across the years. It provides an industry’s perspective of what has changed and what has remained on top of mind for IT and business executives. The perennial concern, IT and business alignment, is explored in grea...

The Sistema Interamericano de Metrologia (SIM) is a regional metrology organization (RMO) whose members are the national metrology institutes (NMIs) located in the 34 nations of the Organization of American States (OAS). The SIM/OAS region extends throughout North, Central, and South America and the Caribbean Islands. About half of the SIM NMIs maintain national standards of time and frequency ...

This paper describes the science scheduling and operation of the Space Interferometry Mission (SIM) as a science instrument. The SIM Science Team has defined a set of science programs to be observed with SIM. The scheduling and operation of SIM, and modeling of the expected performance, differs significantly from other astrometric or imaging space-based telescopes. A timeline of observations is...

BACKGROUND AND PURPOSE The purpose of this study was to determine the incidence of susceptibility artifacts on functional MR imaging (fMRI) studies and their effect on fMRI readings. We hypothesized that the availability of the signal intensity maps (SIMs) changes the interpretation of fMRI studies in which susceptibility artifacts affected eloquent brain regions. METHODS We reviewed 152 cons...

We present numerical simulations for a possible synthesis imaging mode of the Space Interferometer Mission (SIM). We summarize the general techniques that SIM offers to perform imaging of high surface brightness sources, and discuss their strengths and weaknesses. We describe an interactive software package that is used to provide realistic, photometrically correct estimates of SIM performance ...