Previous knowledge of silicosis in the Swedish granite industry suggested that the disease was neither common nor severe. In recent years, however, changes in working methods have involved a considerably increased formation of dust, and it was considered likely that the risk of contracting silicosis was increased. Reports from other countries supported this conjecture. The 34 known cases of sil...

ilicosis is a potentially fatal, irreversible, fibrotic pulmonary disease that ay develop subsequent to the inhalation of large amounts of silica dust ver time. In most circumstances, silicosis only develops subsequent to ubstantial occupational exposures. The disease has a long latency period nd may clinically present as an acute, accelerated, or chronic disease. The pathophysiology of chronic...

Validations of retrospective methods of assessment used in occupational epidemiological studies have rarely been published. This study is an indirect validation of a quantitative retrospective assessment of exposure to silica used in a nested case-control study of lung cancer among workers at 29 metal mines and pottery factories in China. Indices of cumulative total dust and cumulative respirab...

BACKGROUND The working environment of stone miners has been believed to cause their susceptibility to respiratory diseases. Silicosis is an occupational disease caused by exposure to crystalline silica dust which is marked by inflammation and scarring in the lung. The immune system boosted after the silica invasion led to self-damage and lay the foundation of silicosis pathogenesis. Silicosis c...

BACKGROUND Silicosis is known in industrial workers for centuries. Till recently, the mainstay of its diagnosis and progress was clinical examination of the respiratory system, pulmonary function test and chest radiography. Several biomarkers such as serum angiotensin converting enzyme (ACE) activity have been examined to determine the extent of silicosis. OBJECTIVE To elucidate the effect of...

Classical radiographic features of patients presenting with silicosis are diffuse interstitial shadowing with subsequent enlargement of hilar nodes, sometimes with "eggshell" calcification. Five case histories are described of workers who were exposed to silica and presented initially with bilateral hilar lymphadenopathy without radiographic evidence of interstitial lung disease. One case progr...

The critical molecular mechanism in the development of the pulmonary fibrosis remains unknown, leaving diagnosed patients with a poor prognosis. To isolate the genes specifically up-regulated in pulmonary fibrosis, we established a rat silicosis model 360 d after treatment with crystalline silica suspension. Radiographs of chests showed that some scattered high-density shadows appeared in the l...

BACKGROUND Production process of most factory-made products is harmful to our health and environment. Silica is the most important stone used in stone cutting factories. Numerous researches have reported respiratory diseases due to the inhalation of these particles in various occupations. Silicosis is a disease with typical radiographic pattern caused as the result of inhalation of silica parti...

The aim of the study is to analyse the profile of the non-specific systemic immune response in a group of subjects with silicosis, that have variable opacities profusion on standard chest X-ray, and to try an estimate of the immune aggression in silicosis, to find a possible association of the humoral immunological parameters with the silicosis evolution stages as a criteria for the disease pro...

OBJECTIVE To describe and analyse the baseline characteristics of workers attending the pneumoconiosis clinic for assessment of silicosis. DESIGN Retrospective cross-sectional study. SETTING Outpatient clinic. PATIENTS One thousand and fifty-six patients with silica dust exposure attending the pneumoconiosis clinic for compensation assessment. MAIN OUTCOME MEASURES Baseline demographic ...