The sigma-receptor, a broadly distributed integral membrane protein with a novel structure, is known to modulate various voltage-gated K(+) and Ca(2+) channels through a mechanism that involves neither G proteins nor phosphorylation. The present study investigated the modulation of the heart voltage-gated Na(+) channel (Na(v)1.5) by sigma-receptors. The sigma(1)-receptor ligands [SKF-10047 and ...

 In Proposition 2.6 in (G‎. ‎Gruenhage‎, ‎A‎. ‎Lutzer‎, ‎Baire and Volterra spaces‎, ‎textit{Proc‎. ‎Amer‎. ‎Math‎. ‎Soc.} {128} (2000)‎, ‎no‎. ‎10‎, ‎3115--3124) a condition that‎ ‎every point of $D$ is $G_delta$ in $X$ was overlooked‎. ‎So we‎ ‎proved some conditions by which a Baire space is equivalent to a‎ ‎Volterra space‎. ‎In this note we show that if $X$ is a‎ ‎monotonically normal $T_1...

Bacterial sigma (sigma) factors are an essential component of RNA polymerase and determine promoter selectivity. The substitution of one sigma factor for another can redirect some or all of the RNA polymerase in a cell to activate the transcription of genes that would otherwise be silent. As a class, alternative sigma factors play key roles in coordinating gene transcription during various stre...

Cruz Biotechnology), anti-FLAG (M2; Sigma Chemical Co., St. Louis, MO), anti-β-actin (AC-15; Sigma), and anti-α-tubulin (B-5-1-2; Sigma Chemical Co.) were used. Anti-Synoviolin monoclonal antibody (10Da) was reported previously (Amano et al., 2003). Cycloheximide (Sigma Chemical Co., 100μg/mL) was used for the chase experiment of p53. Camptothecine (Sigma, 0.5 mM), and actinomycin D (Sigma Chem...

studies pertaining convergence and its benefits for developing and underdeveloped countries, specifically latin american countries and the caribbean islands are essential because they can create the necessary grounds for further growth and development. the aim of this study is to analyze the economic growth of latin american countries and the caribbeans after their beta and sigma convergences d...

sigma(B), the general stress response sigma factor of Bacillus subtilis, is activated when the cell's energy levels decline or the bacterium is exposed to environmental stress (e.g., heat shock, ethanol). Physical stress activates sigma(B) through a collection of regulatory kinases and phosphatases (the Rsb proteins) which catalyze the release of sigma(B) from an anti-sigma(B) factor inhibitor....

A hallmark of sporulation of Bacillus subtilis is the formation of two distinct cells by an asymmetric division. The development programs in these two cells involve the compartmentalized activities of sigma E in the larger mother cell and of sigma F in the smaller prespore. Activation of sigma E requires expression of the sigma F-directed gene spoIIR. By immunofluorescence microscopy of a strai...