Sickle cell anaemia is a major chapter within haemolytic anaemias; at the same time, its epidemiology is a remarkable signature of the past and present world distribution of Plasmodium falciparum malaria. In this brief review, in keeping with the theme of this journal, we focus on the close and complex relationship betweeen this blood disease and this infectious disease. On one hand, heterozygo...

background: until now, trimodal distribution of hbs has been seen by six different studies in the world when associated with alpha-thalassemia with confirmation by corresponding alpha-genotyping studies. the rbc indices reduce as alpha-globin genes reduce in sickle cell trait (sct) patients, which decreases the extent of intra-vascular sickling and thus betters the clinical course of the patien...

Sickle cell trait is not usually regarded as a disease state because it has complications that are either uncommon or mild. Nevertheless, under unusual circumstances, serious morbidity or mortality can result from complications related to polymerization of deoxy-hemoglobin S. A previous study was earlier conducted to study Sickle cell traits and it revealed that there was enhanced lipid per oxi...

The inherited disorders of haemoglobin are the commonest monogenic diseases. It has been estimated that over 300 000 babies are born each year with one of these conditions, either sickle-cell disease or severe forms of thalassaemia. Normal adult haemoglobin (HbA) consists of two aand two b-globin chains (a2b2), each with an associated heme group, which are regulated by duplicated HBA1 genes and...

Objectives : To study the surgical presentations of sickle cell anaemia (SCA) in a sickle cell belt in India and to discuss the historical aspects and pathophysiology of sickling and its sequelae. Methodology : One hundred patients attending the surgical outpatient were screened for Sickle cell disease and the signs and symptoms were recorded as to the type of crisis they presented with. Result...

BACKGROUND Sickle cell disease (SCD) is a more common and severe disease in Africa. Nigeria the most populous black nation in Africa has the largest number of sickle cell anaemia (SCA) patients in the world. Borno and Yobe State has the largest number of sickle cell trait in Nigeria with prevalence of 27.9% and 32.6% respectively. Sickle cell anaemia survival to adulthood in Africa was reporte...