background: the aim of this study was to determine the serotypes and antimicrobial susceptibility of shigella spp. in isfahan, (iran) from 2010 to 2015.   methods: this retrospective study was conducted on shigella isolates in four tertiary care hospitals. the process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. the patients we...

background: the aim of this study was to determine the serotypes and antimicrobial susceptibility of shigella spp. in isfahan, (iran) from 2010 to 2015.   methods: this retrospective study was conducted on shigella isolates in four tertiary care hospitals. the process of bacterial isolation and determination of susceptibility was performed by standard microbiological guidelines. the patients we...

Vaccination appears to be the only rational prophylactic approach to control shigellosis. Unfortunately, there is still no safe and efficacious vaccine available. We investigated the protection conferred by a new vaccine containing outer membrane vesicles (OMVs) from Shigella flexneri with an adjuvant based on nanoparticles in an experimental model of shigellosis in mice. OMVs were encapsulated...

Twenty-seven Navajo adults with moderate to severe acute inflammatory diarrhea were hospitalized and randomly given ampicillin or sulfamethoxazole-trimethoprim. All patients had invasive diarrhea as defined by sheets of fecal leukocytes, seen on methylene blue wet-slide preparations, and significant clinical symptoms, including postural hypotension from dehydration or fever (temperature greater...

The Shigella flexneri 2a SC602 vaccine candidate carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin) (S. Barzu, A. Fontaine, P. J. Sansonetti, and A. Phalipon, Infect. Immun. 64:1190-1196, 1996). Dose selection studies showed that SC602 causes shigellosis in a majority of volunteers when 3 x 1...

BACKGROUND Cholera and shigellosis are endemic on the Indian subcontinent. Our objective was to identify cholera-specific risk factors distinct from shigellosis risk factors. METHODS We conducted a case-case study among hospitalized diarrheal patients, comparing those with cholera and shigellosis in International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) hospitals in Matlab...

The association between the period elapsed since weaning and the risk of shigellosis was assessed between 1 November 1987 and 30 November 1989 for a cohort of 1085 Bangladeshi children aged < 3 years. The children were followed for 1 month after exposure to Shigella spp. in their residential neighbourhoods, and the 268 who developed microbiologically confirmed (n = 118) or clinically presumptiv...

To prepare a field site for evaluating preventive interventions against endemic shigellosis, the authors followed prospectively a cohort of 360 children (90 each of children aged 0-11, 12-23, 24-35, and 36-47 months) in Santa Julia, a low socioeconomic area in Santiago, Chile, from November 1986 through April 1989 with twice weekly household visits for diarrheal disease; infants replaced childr...

Background and aims: Shigellosis or bacillary dysentery is an infectious disease transmitted through water and food. It is a type of infectious colitis caused by Shigella bacteria. The aim of this study is to determine the prevalence and the spatial distribution of shigellosis and its relationship with climatic factors in Chaharmahal and Bakhtiari province. Methods: In this study, population of...