We studied the relationship between the degree of mitral protrusion and degree of mitral regurgitation in an experimental model in which the degree of mitral protrusion could be adjusted. The model was developed by dissecting the dorsal papillary muscle through a left atriotomy in 5 dogs and re-attaching the papillary muscle to the original site using a single mattress suture threading through ...

Integrin-mediated adhesion is a critical regulator of cell migration. Here we demonstrate that integrin-mediated adhesion to high fibronectin concentrations induces a stop signal for cell migration by inhibiting cell polarization and protrusion. On fibronectin, the stop signal is generated through alpha 5 beta 1 integrin-mediated signaling to the Rho family of GTPases. Specifically, Cdc42 and R...

Integrin-mediated adhesion is a critical regulator of cell migration. Here we demonstrate that integrin-mediated adhesion to high fibronectin concentrations induces a stop signal for cell migration by inhibiting cell polarization and protrusion. On fibronectin, the stop signal is generated through a5b1 integrin-mediated signaling to the Rho family of GTPases. Specifically, Cdc42 and Rac1 activa...

The aim of the current study was to examine matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) expression in patients with cervical disc herniation (CDH). A total of 127 specimens from CDH patients undergoing posterior spinal surgery were obtained for the case group, which was divided into three subgroups: lateral protrusion (N = 102), median protrusion (N =...

This paper examines whether lip protrusion is affected by initial strengthening of rounded vowels in French. Three speakers produced sentences containing the vowels /i, e, ɛ, a, y, ø, œ, u, o, ɔ/ at the beginning of different prosodic constituents: Intonational Phrase (IP), Accentual Phrase (AP) and Word (W). Using video and Qualisys motion capture data, three parameters (lip protrusion, area/l...

Recent studies have demonstrated that actin filaments are not crucial for the short-term stability of tubular membrane protrusions originating from the cell surface. It has also been demonstrated that prominin nanodomains and curvature inducing I-BAR proteins could account for the stability of the membrane protrusion. Here we constructed an axisymmetric model of a membrane protrusion that exclu...

The ability to protrude the jaws during prey capture is a hallmark of teleost fishes, widely recognized as one of the most significant innovations in their diverse and mechanically complex skull. An elaborated jaw protrusion mechanism has independently evolved multiple times in bony fishes, and is a conspicuous feature in several of their most spectacular radiations, ultimately being found in a...

OBJECTIVE To analyze the pre-treatment cephalometric features in Saudi adults with bimaxillary protrusion and to develop cephalometric standards to clarify the overall presentation of this malocclusion for clinicians. METHODS A descriptive retrospective study was designed in which lateral cephalometric radiographs of 60 individuals with Class I skeletal and dental relationship and decreased i...

BACKGROUND AND PURPOSE Subjective determination of the posterior sclera flattening and optic nerve protrusion in MRI is challenging because of the 3D nature of the globe morphology. This study aims to develop and compare quantitative measures of globe flattening and optic nerve protrusion with subjective rating, and assess relationships with papilledema grade and intraocular and CSF pressures. ...

A 65-year-old woman was referred to the Department of Cardiovascular Surgery of our hospital for an operation with a presumptive diagnosis of right atrial myxoma. The mass was found incidentally on routine echocardiography during preoperative evaluation for total knee replacement. She had had hypertension and diabetes mellitus for 8 years. Her waist circumference was 111 cm and her body mass in...