A line-focus ultrasonic SH-wave probe is developed for possible application to TOFD method. The probe is composed of a quarteror half-cylindrical wedge and a piezoelectric transducer adhered to the cylindrical surface of the wedge. An SH-wave pulse with cylindrical wave front is generated by the transducer, transmitted to the wedge, and focused on a line at the bottom surface of the wedge. Henc...

introduction: during the last 3 decades, human is exposed to extremely low frequency electromagnetic fields (elf-emf) emitted by power lines and electronic devices. it is now well accepted that elf-emf are able to produce a variety of biological effects, although the molecular mechanism is unclear and controversial. investigation of different intensities effects of 50 hz elf-emf on cell morphol...

OBJECTIVE Neuroblastoma is one of common childhood tumors. Although its mortality is very high, there is no effective treatment yet. The aim of this project is to evaluate cytotoxic effects of melatonin (MLT) an endogen hormone and 13-cis retinoic acid (13-cis-RA) also named as isotretinoin an analogue of vitamin A on neuroblastoma SH-SY5Y cell line. METHODS In this study, SH-SY5Y cell line w...

The signaling pathway for DNA damaging drug-triggered apoptosis was examined in a chemosensitive human neuroblastoma cell line, SH-SY5Y. Doxorubicin and etoposide induce rapid and extensive apoptosis in SH-SY5Y cells. After the drug treatment, p53 protein levels increase in the nucleus, leading to the induction of its transcription targets p21(Waf1/Cip1) and MDM2. Inactivation of p53, either by...

Tosetti, Patrizia, Vanni Taglietti, and Mauro Toselli. Functional sium channel (hPCN1) was expressed and studied in Xenochanges in potassium conductances of the human neuroblastoma pus oocytes (Philipson et al. 1991). A Shaker potassium cell line SH-SY5Y during in vitro differentiation. J. Neurophysiol. channel, classified as Kv1.5, was cloned from human heart 79: 648–658, 1998. The electrophys...