نتایج جستجو برای: sglt2 inhibitor
تعداد نتایج: 211924 فیلتر نتایج به سال:
Aminoglycoside antibiotics, like gentamicin, continue to be clinically essential worldwide to treat life-threatening bacterial infections. Yet, the ototoxic and nephrotoxic side-effects of these drugs remain serious complications. A major site of gentamicin uptake and toxicity resides within kidney proximal tubules that also heavily express electrogenic sodium-glucose transporter-2 (SGLT2; SLC5...
This Article contains errors in the Acknowledgements section. " The authors acknowledge funding support from the National Health and Medical Council of Australia (1004926). " should read: " The authors acknowledge funding support from the National Health and Medical Research Council of Australia (1004926) and Diabetes Australia. " This work is licensed under a Creative Commons Attribution 4.0 I...
The second member of the Na(+)/glucose cotransporter family, SGLT2, is a low-affinity active glucose transporter. In humans, it is predominantly located on the apical membrane of the S1 and S2 segments of renal proximal convoluted tubules, and, thus, may be mainly responsible for the reabsorption of D-glucose from the glomerular filtrate. By BLAST searching the GenBank database, we found expres...
Abstract Background Diabetes clinical trials have shown SGLT inhibition improves cardiovascular outcomes, yet the mechanism is not fully understood. Hyperglycemia a common finding in diabetic and non-diabetic patients presenting with ACS powerful predictor of prognosis mortality. The role hyperglycemia ischemia-reperfusion injury (IRI) understood, whether Sodium Glucose Co-Transporter 1 (SGLT1)...
SHORT syndrome is a rare developmental disorder frequently associated with growth failure and insulin resistant diabetes mellitus (IRDM). Since GH has diabetogenic effect, therapy been regarded as contraindication. We observed Brazilian girl who received from 4 6/12 years of age for SGA short stature. dosage was increased 0.23 to 0.36 mg/kg/week, but statural response remained poor. Her blood H...
On behalf of the 48 coauthors from our article reporting the findings and recommendations of the 2nd Diabetes Surgery Summit (DSS-II) (1), we sincerely thank Aberle and Göke (2) for their insightful comments about the consideration of sodium–glucose cotransporter 2 (SGLT2) inhibitors to treat type 2 diabetes (T2D) shortly after bariatric/metabolic surgery. The DSS-II was a consensus development...
If you are wondering what health care disparities might look like in medication use for chronic diseases, a new study published JAMA Network Open can serve as just one example. Among patients with diabetes the United States, researchers found that lower rates of SGLT2 inhibitor use, substantial cardioprotective and kidney protective benefits, is associated Black race, Asian female gender, house...
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