Serum aspartate aminotransferase isoenzymes were measured in 123 hospital patients with various liver diseases, using a new and simple immunochemical method. Our findings show the usefulness of this determination in estimating the severity of hepatic damage, especially if accompanied by the measurement of other mitochondrial enzymes. During hepatic damage, the cytoplasmic isoenzyme is found in ...

This research investigated the protective role of Leea macrophylla extract on CCl4-induced acute liver injury in rats. Different fractions of Leea macrophylla (Roxb.) crude extract were subjected to analysis for antioxidative effects. Rats were randomly divided into four groups as normal control, hepatic control, and reference control (silymarin) group and treatment group. Evaluations were made...

PURPOSE To analyze the role of hyperbaric oxygen therapy as hepatic preconditioning in rats submitted to hepatic ischemia and reperfusion. METHODS Wistar rats were randomly divided into three groups: SHAM, rats submitted to surgical stress without hepatic ischemia and reperfusion, I/R, rats submitted to total hepatic pedicle ischemia for 30 min, followed by 5 min of reperfusion; HBOI/R, rats ...

Ad (1): All Wve cases had serum creatinine concentrations within the reference limits of our laboratory. Determination of blood urea nitrogen is not a clinical routine in our department. As regards serum transferases, case No. 3 had a slight, transient rise initially [aspartate aminotransferase: 0.88 (upper reference limit 0.60) kat/L; alanine aminotransferase: 1.1 (0.75) kat/L)], while all the...

The classic signs and symptoms of rhabdomyolysis are non-specific and not present in all cases, and mild cases might go unrecognized. We present a case of rhabdomyolysis recognized in a 68-year-old man after elevation of liver enzymes following prolonged urologic surgery. The patient's postoperative course was concerned with elevated serum aspartate aminotransferase and alanine aminotransferase...

The present study examined the impact of Lufenuron on biochemical parameters of albino mice.The biochemical parameters such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST) and Alkaline phosphatase (ALP) and Total protein in serum were observed. The mice exposed with Lufenuron 0.1520 mg/kg) for 30 days. The present study suggests that the level of AST, ALT and ALP were increa...

Elevated enzyme activities in plasma may sometimes be due to the presence of macroenzymes.1,2 Macroenzymes are high molecular mass complexes of plasma enzymes with immunoglobulins (IgG, IgA or IgM) or other plasma components with reduced plasma clearance and prolonged half life, resulting in elevated serum activities due to the “trapping” of the enzymes in serum.3 These results may thus be erro...

Wolf et al. (1) found little or no serum aspartate aminotransferase (EC 2.6.1.1) activity in the sera of 11 of 19 patients undergoing long-term hemodialysis. The authors concluded that low aminotransferase (transaminase) activities seen in these patients may have been due to loss of the enzyme and (or) to pynidoxine depletion during long-term dialysis. We recently examined the sera of 54 long-t...

The present study was aimed to evaluate the phytochemical, antidiabetic, and cytoprotective properties of Berberis aristata DC. (Berberidaceae) root extracts. After phytochemical evaluation of various extracts of B. aristata roots, the ethanol extract was found to be rich in phytochemicals with the presence of alkaloid determined by the thin layer chromatography; hence ethanol extract was selec...