ON THE INNER FRONT COVER: Septin‐caged Shigella flexneri in infected HEK293 cells. Bacteria and actin are labelled red, SEPT7 green, DNA blue. Credit: Gizem Ozbaykal‐Guler Serge Mostowy, London School of Hygiene & Tropical Medicine image

The mixed lineage leukemia (MLL) locus is involved in more than 60 different rearrangements with a remarkably diverse group of fusion partners in approximately 10% of human leukemias. MLL rearrangements include chromosomal translocations, gene internal duplications, chromosome 11q deletions or inversions and MLL gene insertions into other chromosomes, or vice versa. MLL fusion partners can be c...

Front Cover: The cover image is based on the Research Article Proper phosphorylation of septin 12 regulates 4 and soluble adenylyl cyclase expression to induce sperm capacitation by Han-Yu Wang et al., https://doi.org/10.1002/jcp.30951.

newly determined structure of a filament-forming protein from bacteria is eerily similar to that of eukaryotic actin. The bacterial protein, MreB, was known to affect cell shape in bacteria; Escherichia coli that lack MreB are spherical rather than rod-shaped. In March of this year, Jeffery Errington and colleagues (University of Oxford, UK) reported that filamentous helical A Actin (left) and ...

While traditional "talk" therapies remain at the foundation of counseling, the use of expressive and creative arts in conjunction with these methods can often deepen the healing process as well as expedite diagnosis, treatment and prevention. Integrating the Expressive Arts into Counseling Practice is designed to provide readers with an understanding of the ways in which expressive arts counsel...

Candida albicans is a major invasive fungal pathogen in humans. An important virulence factor is its ability to switch between the yeast and hyphal forms, and these filamentous forms are important in tissue penetration and invasion. A common feature for filamentous growth is the ability to inhibit cell separation after cytokinesis, although it is poorly understood how this process is regulated ...

Saccharomyces cerevisiae cells growing in the outdoor environment must adapt to sudden changes in temperature and other variables. Many such changes trigger stress responses that delay bud emergence until the cells can adapt. In such circumstances, the morphogenesis checkpoint delays mitosis until a bud has been formed. Mitotic delay is due to the Wee1 family mitotic inhibitor Swe1p, whose degr...

Glc7, the type1 serine/threonine phosphatase in the yeast Saccharomyces cerevisiae, is targeted by auxiliary subunits to numerous locations in the cell, where it regulates a range of physiological pathways. We show here that the accumulation of Glc7 at mating projections requires Afr1, a protein required for the formation of normal projections. AFR1-null mutants fail to target Glc7 to projectio...