Early approaches to the development of oxygen carriers involved the use of stroma-free hemoglobin solutions. These solutions did not require blood typing or crossmatching and could be stored for long periods. In addition, a variety of methods have been developed in chemically modifying and stabilizing the hemoglobin molecule. Several hemoglobin therapeutics are now in clinical trials as tempora...

To construct a robust morbidity risk-prediction model based on a Japanese nationwide web-based database of patients who underwent liver surgery.Although liver resection has become safer, patient mortality and morbidity still occur. This study investigated postoperative morbidity risks in patients who underwent hepatectomy in Japan at institutions registered in the National Clinical Database.Thi...

background and objectives: hydrocortisone is widely used in septic shock cases resistant to fluid and vasopressor therapy. it may result in increased blood pressure and survival. however the efficacy is no established among patients with severe burn and septic shock. accordingly it was assessed in this study. materials and methods: the patients older than 14 years of age with resistant septic s...

Aim: It is aimed in this study to determine blood and blood component’s transfusion indications, component using rate, early transfusion complications and the distribution of complications according to the blood component. Method: In this study, recipient’s name, surname, age, gender, blood component, the clinic where transfusion have done, transfusion indications, whether or not transfusion hi...

OBJECTIVES In children with severe sepsis or septic shock, the optimal red blood cell transfusion threshold is unknown. We analyzed the subgroup of patients with sepsis and transfusion requirements in a pediatric intensive care unit study to determine the impact of a restrictive vs. liberal transfusion strategy on clinical outcome. DESIGN Subgroup analysis of a prospective, multicenter, rando...

OBJECTIVE To analyze the profile of blood transfusion reactions in children and to identify the involved factors. METHODS This was a cross-sectional study in a tertiary pediatric teaching hospital from the public healthcare system, involving all children admitted from January to July of 2011 (5,437), of which 1,226 received blood transfusions, constituting the sample. A documental study was p...

BACKGROUND The indirect antiglobulin test (IAT) can be potentiated by agents such as polyethylene glycol (PEG-IAT) and albumin (Alb-IAT). PEG-IAT is generally regarded as superior to Alb-IAT for the detection of clinically significant red blood cell (RBC) antibodies. However, supporting data come from Caucasian-dominant populations. Non-Caucasian populations should be investigated as well. MA...

BACKGROUND In recent years, pulmonary transfusion reactions have gained increasing importance as serious adverse transfusion events. METHODS Review of the literature. RESULTS Pulmonary transfusion reactions are not extremely rare and, according to hemovigilance data, important causes of transfusion-induced major morbidity and death. They can be classified as primary with predominant pulmona...

BACKGROUND Anti-IH is usually a clinically insignificant antibody that may complicate a serologic workup. However, it can occasionally cause hemolysis. We report a rare case of acute hemolysis caused by anti-IH. CASE REPORT A 60-year-old man with a long history of chronic myelomonocytic leukemia and anemia, blood group A, D+ was found to have an unidentified antibody on serologic workup. He r...